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Category: Volume 08 Issue 03 March 2020
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Title: A Comparative Study of Thyroid Profile in Individuals with and Without Metabolic Syndrome

Authors: Dr Subhasish Deb, Dr Amit Sarkar, Dr Somnath Dasgupta, Dr Ashish P Dudhe, Dr Agnibha Dutta

 DOI: https://dx.doi.org/10.18535/jmscr/v8i3.04

Abstract

   

Metabolic syndrome  is increasingly  recognised  as  emerging  threats  to  health  of  human  race. Thyroid hormones up regulate metabolic pathways relevant to resting energy expenditure. Obesity causes alteration in thyroid function tests. We compared the thyroid profiles of individuals with and without Metabolic Syndrome and assessed the possibility of obesity influencing the results. This is a cross sectional study which includes 200 patients above the age of 18 years attending the outpatient department of our institution from January 2015 to August 2016. They were divided into four groups where group 1 consists  of  patients with Metabolic syndrome and obesity, group 2 with Metabolic Syndrome without obesity, group 3 without Metabolic syndrome but obese and group 4 without Metabolic syndrome and non obese. The NCEP ATP III criteria was used for assessing Metabolic syndrome and revised consensus guidelines for Asian Indians was chosen to determine the Body Mass Index (BMI) for obesity. TSH, T4, T3 were measured as indicators of thyroid function. The difference in mean TSH levels between individuals with Metabolic Syndrome (3.84 ± 2.44uIU/L) and without Metabolic Syndrome (2.10±1.70uIU/L) was statistically significant (p = £ 0.05) while the mean T4 and T3 levels were comparable. Amongst individuals with metabolic syndrome ,difference of mean TSH between  obese and  non-obese group  was not significant (p=0.984). Individuals with Metabolic syndrome have a higher TSH level but normal T3 and T4 levels. This rise in TSH is independent of obesity.

Keywords: Metabolic syndrome, Thyroid profile.

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Corresponding Author

Dr Amit Sarkar

Burdwan Medical College and Hospital, P.O. Burdwan, Pin – 713104, District – East Burdwan, West Bengal, India