Title: Bilateral Synchronous ureteric Transional Cell Carcinoma presenting with oliguria – A Case Report

Authors: Maria Amanda L. Cardoso, Pankaj D. Chari, Veku A. Gaude, Rajesh G. Halarnakar, Prashant T.N. Mandrekar, Prashant R. Lawande, Nilesh B. Talwadker, Madhumohan R. Prabhudessai

 DOI: https://dx.doi.org/10.18535/jmscr/v8i1.169

Abstract

Upper tract urothelial carcinomas account for 5% of urothelial tumors. Urothelialtumors of pelvis are more common than that of the ureter, of which 24% occur in mid ureter. Bilateral synchronous Upper Tract TCC (transitional cell carcinoma) is rare with few reports in literature. This is a  case report of a 43 year old male who presented with oliguria & abdominal pain for 3 days. On examination patients vitals were stable. Abdominal examination was unremarkable and bladder was not palpable. On investigation Ultrasound showed bilateral Hydronephrosis with hydro ureter till mid ureter, distal ureters obscured, and bladder was   normal. Plain CT abdomen confirmed ultrasound findings. No was calculus seen. Blood investigations revealed a raised Sr.creatinine of 9.5mg/dl. With a provisional diagnosis of retroperitoneal fibrosis, patient was taken up for Bilateral RGP & DJ stenting.  RGP revealed Bilateral mid Ureteric stricture, stenting was not possible and procedure abandoned.  Patient was planned for left sided exploration. OT finding revealed left Pyelonephritic kidney, upper ureteric mass with dilation of ureter till mid ureter (Stricture site).Patient underwent Segmental ureterectomy with uretero-ureterostomy with DJ stenting. Histopathological examination revealed High grade solid urothetial carcinoma of ureter. Standard management of UTTCC is nephroureterectomy with cuff of bladder; however endoscopic management is being considered a good option in select patients.

Keywords: Bilateral, synchronous, ureteric, transitional cell carcinoma.

References

  1. Hall MC, Womack S, Sagalowsky AI, Carmody T, Erickstad MD, Roehrborn CG. Prognostic factors, recurrence, and survival in transitional cell carcinoma of the upper urinary tract: a 30-year experience in 252 patients. Urology 1998;52:594–601.
  2. Kirkali Z, Tuzel E. Transitional cell carcinoma of the ureter and renal pelvis. Crit Rev Oncol Hematol 2003;47:155–169.
  3. Chih-hsiung Kang, et al. Synchronous bilateral primary transitional cell carcinoma of the upper urinary tracts: Ten patients of more than five years of follow-up UROLOGY 63: 380i-380iii, 2004.
  4. Melamed MR, Reuter VE. Pathology and staging of urothelial tumors of the kidney and ureter. Urol Clin North Am 1993;20:333–347.
  5. Buckley JA, Urban BA, Soyer P, Scherrer A, Fishman EK. Transitional cell carcinoma of the renal pelvis: a retrospective look at CT staging with pathologic correlation. Radiology 1996; 201:194–198.
  6. Chen GL, Bagley DH. Ureteroscopic management of upper tract transitional cell carcinoma in patients with normal contralateral kidneys. J Urol 2000;164: 1173–6.

Corresponding Author

Maria Amanda L Cardosos

Department of Urology, Goa Medical College, Goa-India