Title: Effect of Intravaginal Isosorbide Mononitrate for First Trimester Preoperative Cervical Ripening
Authors: Dr Tanu Sharma, Dr P. B. Jaju
DOI: https://dx.doi.org/10.18535/jmscr/v8i1.112
Abstract
To compare the safety and efficacy of intravaginal administration of isosorbide mononitrate tablet as pre-surgical cervical ripening agent with those of intravaginal application misoprostol tablets before MVA for first trimester termination of pregnancy.
Methodology: It was randomized trial control study with conducted on 50 women, randomly divided into 2 groups- A and B. The women in group A were given Isosorbide mononitrate tablet(two 20 mg tablets) into the posterior fornix of vagina 3 hrs before MVA.
Results: In Group A 36% required further dilatation, in Group B 16% required further dilatation, In Group A 64% & Group B- 84% did not require further dilatation. And we have found statistically significant p value in Group B in respect of Group A i.e (0.02).
Conclusion: To conclude this study reveals that intravaginal Misoprostol can also be used as an effective and safe alternative to Isosorbide mononitrate for cervical ripening prior to first trimester surgical termination of pregnancy.
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