Details
Category: Volume 08 Issue 01 January 2020
Hits: 925

Title: Histological heterogeneity of tumours of female genital tract- an observation from commentary box of a tertiary care hospital in eastern India

Authors: Dr Manisha Mahata, Dr Sanghamitra Mukherjee, Dr Sarbashis

 DOI: https://dx.doi.org/10.18535/jmscr/v8i1.104

Abstract

Cases of gynaecological malignancies are common albeit speculative in some instances owing to the marked sequential cyclic changes the female genital tract undergoes in a lifetime and also the amplitude of heterogeneity it can present with. Five selected cases posing considerable diagnostic challenges are presented here, among the Cases of Gynecological malignancies those were studied over the period of 3 years. Epithelioid leiomyosarcoma involving uterine corpus and unilateral ovary, high grade serous carcinoma with diffuse involvement of bilateral ovaries as well as endometrium and metastasis from occult gall blaadder carcinoma to bilateral cystic ovaries are the first three cases. A case of uterine carcinosarcoma in a younger lady and an immature teratoma of ovary presenting with extensive gliomatosis peritonei are included in the last two cases. Each of these cases posed some unique diagnostic challenges as a virtue of their own.

Keywords: Epitheloid leiomyosarcoma, high grade serous carcinomas, metastatic gall bladder cancer, carcinosarcoma uterus, Immature Teratoma, gliomatosis peritonei.

References

  1. Rosai and Ackermann’s surgical pathology, eleventh edition
  2. WHO classification of tumours of female genital tract, fourth edition
  3. Monica Dandapani, Brandon-Luke L. Seagle, Amer Abdullah, Bryce Hatfield, Robert Samuelson, and Shohreh Shahabi, “Metastatic Uterine Leiomyosarcoma Involving Bilateral Ovarian Stroma without Capsular Involvement Implies a Local Route of Hematogenous Dissemination,” Case Reports in Obstetrics and Gynecology, vol. 2015, Article ID 950373, 5 pages, 2015. h524ttps://doi.org/10.1155/2015/950373
  4. Shondell M. Bouiea Bernadette Cracchiolob Debra Hellera, Epithelioid leiomyosarcoma of the ovary, J Postgrad Med 1993;39:151
  5. J. Alvarado Gay and E. Vega Silva, “Uterine leiomyosarcoma. A report of a case,” Ginecologia y Obstetricia de Mexico, vol. 73, no. 1, pp. 54–58, 2005 (Spanish)
  6. Shakfeh SM, Woodruff JD, Primary ovarian sarcomas: report of 46 cases and review of the literature, Obstet Gynecol Surv. 1987 Jun;42(6):331-49.
  7. Dixit S, Singhal S, Baboo H A, Vyas R K, Neema J P, Murthy R, Sooryanaraya U. Leiomyosarcoma of the ovary. J Postgrad Med 1993;39:151
  8. Makris GM, Manousopoulou G, Battista MJ, Salloum I, Chrelias G, Chrelias C. Synchronous Endometrial and Ovarian Carcinoma: A Case Series. Case Rep Oncol. 2017;10(2):732–736. Published 2017 Aug 9. doi:10.1159/000479501
  9. Sehgal Shivali, Agarwal Shilpi Synchronous primary serous carcinoma of the endometrium and bilateral ovaries National journal of laboratory medicine,2017,july,vol-6(3) PC01-03
  10. Kumar Y, Chahal A, Garg M, Bhutani A. Occult gallbladder carcinoma presenting as a primary ovarian tumor in two women: two case reports and a review of the literature. J Med Case Rep. 2010;4:202. Published 2010 Jun 30. doi:10.1186/1752-1947-4-202
  11. Young Robert H.; Scully, Robert E. Ovarian metastases from carcinoma of gall bladder and extrahepatic bile ducts simulating primary tumours of the ovary: a report of six cases
  12. International Journal of Gynecological Pathology January 1990 volume 9 issue 1 Meyer, R.: in Veit-Stoeckel et al : 770-774, I930.
  13. Emoto M., Iwasaki H., Kikuchi M.,Ishiguro M.Kubota T., Izumi H.,Shirakawa K., Kaneko Y., Two cell lines established from mixed müllerian tumors of the uterus. Morphologic, immunocytochemical, and cytogenetic analyses, Cancer, 1992, 69(7):1759–1768
  14. Gorai I., Yanagibashi T., Taki A. Udagawa K., Miyagi E., Nakazawa T., Hirahara F., Nagashima Y., Minaguchi H., Uterine carcinosarcoma is derived from a single stem cell: an in vitro study, Int J Cancer, 1997, 72(5):821–827.
  15. Amr S. S., Tavassolif. A., Hassan A. A., Issa A. A., Madanat F. F., Mixed mesodermal tumor of the uterus in a 4-year-old girl, 1986, Int J Gynecol Pathol, 5(4): 371–378.
  16. Norris HJ, Zirkin HJ, Benson WL. Immature (malignant) teratoma of theovary:a clinical and pathological study of 58 cases. Cancer 1976;37:2359-2372.
  17. Heifetz SA, Cushing B, Giller R, Shuster JJ, Stolar CJ, Vinocur CD, et al. Immature teratomas in children: Pathologic considerations- A report from the combined pediatric oncology group/children’s cancer group. Am J Surg Pathol 1998;22:1115-24.
  18. Thulerbach WM, Scully RE. Solid teratoma of the ovary: A clinicopathological analysis of 9 cases. Cancer 1960;13:804-10.
  19. Gershensos DM, del JG, Silva EG, Copeland LJ, Wharton JT, Rutledge FN. Immature teratoma of the ovary. Obstet Gynecol 1986;68:624-9.
  20. Gershenson DM. Management of ovarian germ cell tumors. J Clin Oncol 2007; 25:2938-43.

Corresponding Author

Dr Sanghamitra Mukherjee

Assistant Professor of RG Kar Medical College Kolkata, India