Title: A hospital based study to evaluate the prevalence of Diabetic nephropathy by considering Microalbuminuria as early risk marker in type 2 diabetic subjects
Author: Dr S. R. Pattanaik
DOI: https://dx.doi.org/10.18535/jmscr/v8i1.82
Abstract
Aim: For progression of nephropathy increase in Microalbuminuria is consider as a one of the major risk factor for Type 2 Diabetes (T2DM). The main aim of the study is to evaluate the correlation between other risk factor and Microalbuminuria in the development of Diabetic Neuropathy (DN) among T2DM subjects.
Methods: For this study 382 subjects were recruited from a hospital OPD in for this study. Medical record were used to collect demographic history like age, duration of T2DM, history of hypertension and Body Mass Index (BMI). Blood specimen was collected to perform pathological test like Glycosylated haemoglobin (HbA1C), fasting blood glucose (FBG), serum uric acid and serum creatinine. By using the dipstick method in early morning urine samples, Microalbuminuria was quantified.
Results: 137 subjects were having high Microalbuminuria. It has been also observed that the subjects who were having higher Microalbuminuria having higher glycemic parameters (both HbA1c and FPG) (p<0.001) and blood pressure (both systolic and Diastolic) (p<0.001) as compare to subjects who had normal Microalbuminuria or normoalbuminuria subjects. It has been also assed that there were also a significant association between other risk factors like duration of T2DM, Age, BMI, serum creatinine with increase in Microalbuminuria.
Conclusion: There were overall very high prevalence of Microalbuminuria was present in this observational study among T2DM subjects who were at high risk of DN. Looking at the future to reduce the high burden of kidney disease among T2DM early detection of higher level Microalbuminuria was of high importance.
Keywords: Microalbuminuria, Glycosylated hemoglobin (HbA1c), Fasting Plasma Glucose (FPG), Blood Pressure (BP), Risk Factors.
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