Title: Multifactorial Risk Factors for Tomours of Upper-Aerodigestive Tract

Authors: Dr Kashmir Ali, Dr Praveen Kumar, Dr Anand Kumar, Dr Mahendra Khinchi

 DOI: https://dx.doi.org/10.18535/jmscr/v8i1.51

Abstract

Background: Many etiological factors contribute to the development of UADT malignancy, Such as the use of all forms of tobacco, alcohol consumption, viruses (HPV), nutritional factors, poor oral hygiene, chronic inflammation, syphilis, sepsis, sunlight (in cases of lip cancer), miscellaneous factors including heat (particularly heat from a pipe stem in cases of lip cancer), and repeated traumatic irritation.

Aims and Objective: To study risk factors associated with tumours of upper aero-digestive tract.

Material and Methods: Here we study various risk factors for 156 cases of UADT at a tertiary care hospital.

Results and Conclusion: People with poor socioeconomic background, mixed diet and poor oral hygiene are more vulnerable to UADT tumours. Smoking was associated with laryngeal malignancy and tobacco chewing was associated with malignancy of oral cavity with P value being <0.005 (significant).

Keywords: Upper areodigestive tract, tumours, cancer.

References

  1. Sajid mir, JB singh et al, JK Practioners 2004, 11(1):17-20.
  2. Silvia Franceschi et al, Smoking and drinking in relation to the cancers of oral cavity, pharynx, larynx and esophagus in northern Italy Cancer Res. 1990; 50: 6502- 6507
  3. Thakur BS oral and oropharyngeal tumours, clinicopathological study of 243 tumours (1991-1997), Karnataka, Karnataka University 1998
  4. Chaudhary b et al, Tumours of UADT
  5. Mehrotra et al, Prevalence of oral premalignant and malignant lesions at a tertiary level hospital in Allahabad, India, Ravi Asian pacific J cancer prev,9, 263-266
  6. Dias GS; A histological and clinical study on oral cancers, descriptive analysis of 365 cases .Med Oral Pathol Oral Cir Bucal.2007 Nov 1;12(7):E474-8
  7. Khandekar SP oral cancers and some epidemiological factors.A hospital based study, Indian Journal of community medicine vol. 31.no.3 july – September 2006
  8. Balram P. oral cancers in southern India: The influence of smoking , drinking, tobacco chewing, and oral hygiene, International Journal of cancer, 2002; 98(3):440-445
  9. Notani jayant ; Role of diet in tumours of UADT, Nutrition and Cancers 1987;10(1-2): 103-113
  10. Nita Chainani-Wu Diet and oral, pharyngeal and esopharyngeal carcinoma, Nutrition and Cancer, 44(2), 104-126.
  11. Fatholah Behnaud; Relationship between oral poor hygiene and broken teeth with oral tongue squamous cell carcinoma. ActaMedicaIranicavol49, no 3 (2011).
  12. Kyung-Ja Cho, Cancers of the Upper Aero digestive Tract in Korea; J Korean Med Sci 2002; 17: 18-22 ISSN 1011-8934
  13. Skarasgard DP et all cancers of upper aero digestive tract in Ontario, Canada and united states., 2000 American cancer society;88;1728-38.
  14. Majid Ezzati et al Role of smoking in global and regional cancer epidemiology: current pattern and data needs. Int. J. cancer: 116.963-971 (2005)
  15. Claudio pelucchi et all Cancer risk associated with alcohol and tobacco use: Focus on upper Aero Digestive tract and liver, Health Risks vol 29, no 3, 2006
  16. Gary J Macfarlane; The influence of Alcohol consumption on worldwide trends in mortality from upper aero digestive tract cancers in men, et al, Epidemiology. Community health 1996; 50:636-639.

Corresponding Author

Dr Peeyush Kumar Saini

Senior Demonstrator, SMS, Medical College and Hospital, Jaipur, India