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Category: Volume 08 Issue 01 January 2020
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Title: Efficacy and Safety of Ormeloxifene versus low dose OCP in the treatment of Abnormal Uterine Bleeding (AUB)

Authors: Shivangni Sinha, Mohan Chandra Regmi, Tarun Pradhan

 DOI: https://dx.doi.org/10.18535/jmscr/v8i1.21

Abstract

Background and Objective: Abnormal uterine bleeding are a common problem that not only affects the quality of life but can have serious adverse consequences as anemia and malignancy and may account for more than 25% of all hysterectomies. Medical management is a challenging task. The objective of this study is to assess improvement in haemoglobin level post treatment, assess subjective improvement in menstrual bleeding pattern and assess patient’s satisfaction level.

Material and Methods: It was a prospective randomised study conducted in B.P. Koirala Institute of Health Sciences. A total of 116 women meeting the inclusion criteria and giving the informed consent were divided into two groups. Group A: OEM 60mg orally twice a week (Wednesday and Saturday) for 12weeks and Group B: Low dose OCP from day 1 for 21days for 3 consecutive cycles. Patients were followed up 3 monthly. Patient's improvement was assessed by performing blood Hb level after completion of therapy.  Subjective assessment was done by menorrhagia impact questionnaire before and after the treatment.

Results: The haemoglobin level post treatment (t=5.274 p<0.05),subjective improvement in menstrual bleeding pattern (z score= 2.82,p=0.004)(z score=2.304,p=0.02) are significant. Women are satisfied with the treatment ( p=0.001)

Conclusion: Ormeloxifene can be considered an effective therapeutic option for the medical management of abnormal uterine bleeding.

Keywords: Ormeloxifene, abnormal uterine bleeding, menorrhagia impact questionnaire.

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Corresponding Author

Shivangni Sinha

Department of Obstetrics and Gynecology, B.P. Koirala Institute of Health Sciences, Dharan, Nepal