Title: The Dilemma of Comorbidity: Borderlands between Bipolarity and Conversion

Authors; Dr Pavithra Arunachaleeswaran, Dr Vinod G Kulkarni, Dr Shashidara HL, Dr Mruthyunjaya N

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.142

Abstract

In this case report, we discuss a case with overlapping features of mania and conversion disorder and discuss the diagnostic dilemma.30yr old married woman, pre-morbidly argumentative and sensitive to criticism, was brought with complaints of episodic altered behaviour for 2 months, in form of physical aggression, episodes of singing and dancing at inappropriate times, proclaiming to be God, with sudden episodes of unresponsiveness, reduced sleep and appetite. Past history of similar illness 3 years ago, with poor treatment compliance. No depressive symptoms during course of illness. MSE: pt not communicative; not cooperative with Placid facial expression; closes her eyes tightly and refuses to open even against efforts.  Management: T. Olanzapine 5mg was started, considering her aggression and manic symptoms. Throughout her hospital stay, aggression/ altered behaviour was not observed.  With the suggestion of discharge only on grounds of improvement, she was noticed to have change in prior behaviour in form of better communication with family members.

Our case attempts to explore the overlap between Bipolar disorder and dissociative disorder with points in favour of both, necessitating a current symptomatic approach and better understanding of the comorbid interface.

References

  1. Sasson Y, Chopra M, Harrari E, Amitai K, Zohar J. Bipolar comorbidity: from diagnostic dilemmas to therapeutic challenge. Int J Neuropsychopharmacol. 2003 Jun;6(2):139–44.
  2. McElroy SL, Altshuler LL, Suppes T, Keck PE, Frye MA, Denicoff KD, et al. Axis I psychiatric comorbidity and its relationship to historical illness variables in 288 patients with bipolar disorder. Am J Psychiatry. 2001 Mar;158(3):420–6.
  3. Pehlivanturk B, Unal F. Conversion disorder in children and adolescents: clinical features and comorbidity with depressive and anxiety disorders. Turk J Pediatr 2000; 42(2) : 132-37.
  4. Sar V, Akyuz G, Kundakci T, et al. Childhood trauma, dissociation, and psychiatric comor- bidity in patients with conversion disorder. Am J Psychiatry 2004; 161(12) : 2271-6.
  5. Pradhan T, Sharan P, Avasthi A. Comorbid dissociative, anxiety and bipolar disorders: A case report. Available from: www.jpps.com.pk/ show_article.php?JID=1&ArtID=27-21
  6. Parikh MN. Mania and Mixed Dissociation (Conversion) Disorder: A Comorbidity. 2012;15:3.
  7. Ghosal MK, Guha P, Sinha M, Majumdar D, Sengupta P. Conversion (dissociative) symptoms as a presenting feature in early onset bipolar disorder: a case series. BMJ Case Rep 2009;2009:bcr01.2009.1448.
  8. Kowatch RA, Youngstrom EA, Danielyan A, Findling RL. Review and meta-analysis of the phenomenology and clinical characteristics of mania in children and adolescents. Bipolar Disord. 2005 Dec;7(6):483–96.
  9. Spiegel D, Loewenstein RJ, Lewis-Fernández R, Sar V, Simeon D, Vermetten E, et al. Dissociative disorders in DSM-5. Depress Anxiety. 2011 Sep;28(9):824–52.
  10. Oedegaard KJ, Neckelmann D, Benazzi F, Syrstad VEG, Akiskal HS, Fasmer OB. Dissociative experiences differentiate bipolar-II from unipolar depressed patients: the mediating role of cyclothymia and the Type A behaviour speed and impatience subscale. J Affect Disord. 2008 Jun;108(3):207–16.
  11. Etkin A, Egner T, Peraza DM, Kandel ER, Hirsch J. Resolving emotional conflict: a role for the rostral anterior cingulate cortex in modulating activity in the amygdala. Neuron. 2006 Sep 21;51(6):871–82.
  12. Krawczyk DC. Contributions of the prefrontal cortex to the neural basis of human decision making. Neurosci Biobehav Rev. 2002 Oct;26(6):631–64.
  13. Critchley HD, Wiens S, Rotshtein P, Ohman A, Dolan RJ. Neural systems supporting interoceptive awareness. Nat Neurosci. 2004 Feb;7(2):189–95.
  14. Chatterjee SS, Pal A, Mallik N, Ghosal M, Saha G. Dissociative Experience in Unipolar and Bipolar Depression: Exploring the Great Divide. Clin Psychopharmacol Neurosci. 2018 Aug;16(3):262–6.
  15. Zarate C, Tohen M. Bipolar disorder and comorbid axis I disorders: diagnosis and management. In: Yatham L, Kusumakar V, Kutcher S, eds. Bipolar Disorder: A Clinician’s Guide to Biological Treatments.New York: Brunner-Routledge; 2002:115-138.
  16. Yatham LN, Kennedy SH, O’Donovan C, Parikh S, MacQueen G, McIntyre R, et al. Canadian Network for Mood and Anxiety Treatments (CANMAT) guidelines for the management of patients with bipolar disorder: consensus and controversies. Bipolar Disord. 2005;7 Suppl 3:5–69.
  17. Ghaemi SN, Bauer M, Cassidy F, et al. Diagnostic guidelines for bipolar disorder: a summary of the International Society for Bipolar Disorders Diagnostic Guidelines Task Force Report. Bipolar Disord.2008; 10:117-128.

Corresponding Author

Dr Pavithra Arunachaleeswaran

Junior Resident, Department of Psychiatry, SS Institute of Medical Science and Research Centre, Davangere