Title: Leiomyosarcoma of Urinary Bladder - a case report and review of the literature

Authors: Lekha Madhavan Nair MD, DNB, Hridaya Nelliparambath Haresh MBBS, Siva Ranjith J MS, Mch, Preethi T R MD, Francis V James MD

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.133

Abstract

Leiomyosarcoma is a rare mesenchymal neoplasm arising from urinary bladder. Surgery is the mainstay of treatment. There is no consensus regarding adjuvant treatment. A 45 year old lady was evaluated for hematuria and cystoscopy showed a solid tumor arising from base of the urinary bladder. She underwent transurethral resection of bladder tumor and was referred to us with a histopathology report of leiomyosarcoma. She underwent radical cystectomy with ileal conduit and received adjuvant chemotherapy in view of high grade histology.

Keywords: Leiomyosarcoma, Urinary Bladder, cystectomy

References

  1. Dahm P, Gschwend JE. Malignant non-urothelial neoplasms of the urinary bladder: a review. EurUrol 2003;44:672-81.
  2. Slaoui H, Sanchez‑Salas R, Validire P, Barret E, Rozet F, Galiano M, et al. Urinary bladder leiomyosarcoma: Primary surgical treatment. Urol Case Rep 2014;2:137‑8.
  3. Rosser CJ, Slaton JW, Izawa JI, Levy LB, Dinney CP. Clinical presentation and outcome of high-grade urinary bladder leiomyosarcoma in adults. Urology 2003;61:1151-5.
  4. Parekh DJ, Jung C, O’Conner J, et al. Leiomyosarcoma in urinary bladder after cyclophosphamide therapy for retinoblastoma and review of bladder sarcomas. Urology. 2002 Jul;60:164.
  5. Labanaris AP, Zugor V, Meyer B, et al. Urinary bladder leiomyosarcoma in adults. Int Urol Nephrol. 2008;40:311e316.
  6. Helen Zieschanga Rainer Kochb Manfred P. Wirtha Michael Froehner. Leiomyosarcoma of the Urinary Bladder in Adult Patients: A Systematic Review of the Literature and Meta-Analysis.
  7. Spiess PE, Kassouf W, Steinberg JR, Tuziak T Hernandez M, Tibbs RF, Czerniak B, Kamat AM, Dinney CP, Grossman HB: Review of the M.D. Anderson experience in the treatmentof bladder sarcoma. UrolOncol 2007;25:38–45.

Corresponding Author

Dr Siva Ranjith J

Assistant Professor, Department of Surgical Oncology, Regional Cancer Centre, Trivandrum