Title: A Prospective Study to Evaluate Causes and Outcomes of Acute Kidney Injury in Patients of Cirrhosis of Liver in a Tertiary Care Centre
Authors: Dr B. Ashok Babu, Dr K.Vidyasagar, Dr R.Ranganadha Rao, Dr M.Madhusudhana Babu
DOI: https://dx.doi.org/10.18535/jmscr/v7i12.131
Abstract
Introduction
Acute kidney injury (AKI) frequently occurs in patients with cirrhosis and was associated with significant mortality.1,2 mortality in cirrhosis has been shown to increase progressively in association with an increase in the severity of AKI.2 The most common causes of AKI in cirrhosis are pre-renal azotemia (volume-responsive pre-renal AKI), acute tubular necrosis (ATN) and hepatorenal syndrome (HRS), a functional type of pre-renal AKI exclusive of cirrhosis that does not respond to volume repletion. Recent studies suggest using the Acute Kidney Injury Network (AKIN) definition of AKI, which closely correlates with mortality in cirrhosis.
Aim of the Study
- To study the incidence of different patterns of AKI in cirrhosis.
- To evaluate the impact of AKI severity on patient survival
References
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- M. Belcher, G. Garcia-Tsao, A. J. Sanyal et al., “Association of AKI With mortality and complications in hospitalized patients with cirrhosis,” Hepatology, vol. 57, no. 2, pp. 753–762, 2013.