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Category: Volume 07 Issue 12 December 2019
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Title: Trends of HBV and HCV co-infection in HIV patients: A fifteen years retrospective study

Authors: Shashi Sudan Sharma, Monika Sharma, Rajiv Kumar Gupta, Preeti Sharma, Ritu Sharma, Radhika Goswami

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.74

Abstract

Aim: Globally, about 30% of HIV infected patients are coinfected with HBV/HCV resulting in 1 million deaths every year. Co-infection with HBV and HCV is common in HIV-infected patients. These co-infections in HIV infected patients complicate the clinical course, management and also adversely affect the therapy for HIV infection. The present study was conducted to determine these infections in HIV infected individuals attending Anti Retroviral Therapy (ART) Centre in a tertiary care hospital in north India.

Methods: A total of three thousand six hundred and sixty-eight (3,668), serum samples received from the ART Centre to the Microbiology laboratory from 1st January 2003 to 31st December 2017 were tested for detection of HBsAg and anti-HCV antibodies by ELISA.

Results: 67(1.82%) were co-infected with HBV or/and HCV. It was found that HIV-HBV/HCV coinfection was predominant in males 43/67 (64.2%). Heterosexual contact was the prevalent mode of acquiring these infections. A preponderance of sexually active age group between 30-50 years was found significantly associated with HIV/HBV/HCV infections.

Interpretation & Conclusion: A declining course of HIV positivity and almost homogenous pattern of HBV and HCV co-infection was observed in the study, demanding a well planned awareness and control programme in place for health education of the high risk groups. Hepatitis virus infection leads to rapid progression of liver cirrhosis in HIV-infected patients hence a routine check-up of HIV seropositive patients for hepatitis virus may be required to monitor clinical outcome.

Keywords: Co-infection, Hepatitis B, Hepatitis C, Human Immunodeficiency Virus.

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Corresponding Author

Dr Monika Sharma

Microbiologist, Department of Microbiology, GMC, Jammu, J&K