Title: Assessment of C-peptide levels in Diabetes mellitus patients and their association with obesity
Authors: Dr Darshana Jain, Dr Fatima Bhopalwala
DOI: https://dx.doi.org/10.18535/jmscr/v7i12.64
Abstract
Background: Diabetes mellitus is a chronic metabolic and endocrine disorder resulting from defects in insulin secretion, insulin action or both. The determination of c-peptide provides an assessment of endogenous secretory reserves in patients with diabetes mellitus and is considered a more reliable indicator of insulin secretion than insulin itself.
Objective: To estimate the C- peptide levels in type 2 diabetics; to assess the endogenous insulin secretary function and to find their association with obesity.
Material and Method: The present study was conducted on 100 adult patients of type 2 Diabetes mellitus presenting in OPD and emergency after taking informed consent and approval from hospital ethical committee. Venous blood sample were withdrawn in the fasting state and C-peptide levels were estimated. Results: Out of 100 patients, 49% patients had fasting C-peptide levels between 1-2 ng/ml. Only 7% patients had<0.6ng/ml. The mean fasting- peptide level of the study was 1.348 ± 0.796.
Conclusion: Raised levels of C-peptide seen in diabetic patients as the resistance to insulin increases hence it can be used as a screening tool.
Keywords: Diabetes Mellitus, C-peptide, Insulin.
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