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Category: Volume 07 Issue 12 December 2019
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Title: Serum uric acid level and its correlation with HbA1c in type 2 Diabetes Mellitus

Authors: Dr Vibha Sushilendu, Dr Narendra Kumar, Dr Rekha Kumari

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.54

Abstract

Diabetes Mellitus is a chronic disorder that is associated with cardiovascular complications, renal complications and various types of microangiopathies including metabolic syndrome. Haemoglobin A1C (Hba1c) is a measure of glycosylated haemoglobin over the period 3 months due to the usual lifespan of erythrocytes of 120 days and is used to monitor control of blood glucose levels in patients with DM. Serum Uric acid is the final oxidation product of purine metabolism in the circulation. A cross-sectional, observational study was conducted over a period of six months. 50 patients of more than 18 years of age diagnosed with type 2 Diabetes Mellitus were included in the study and 50 age and sex matched healthy controls were taken. In this study a negative correlation between serum uric acid and HbA1c was observed in patients with type 2 Diabetes Mellitus.

Keywords: Diabetes Mellitus, HbA1c, uric acid.

References

  1. Akhtar SN, Dhillon P. Prevalence of diagnosed diabetes and associated risk factors: Evidence from the large-scale surveys in India. Journal of Social Health and Diabetes 2017;1;5:28.
  2. Cui Y, Bu H, Ma X, Zhao S, Li X, Lu S. The relation between serum uric acid and HbA1c is dependent upon hyperinsulinemia in patients with newly diagnosed type 2 diabetes mellitus. Journal of diabetes research. 2016; 2016.
  3. Lv Q, Meng XF, He FF, Chen S, Su H, Xiong J, Gao P, Tian XJ, Liu JS, Zhu ZH, Huang K. High serum uric acid and increased risk of type 2 diabetes: a systemic review and meta-analysis of prospective cohort studies. PloS one. 2013; 8(2):e56864. https://doi.org/10.1371/journal.pone.0056864 PMid:23437258 PMCid:PMC3577701
  4. Qiu Q, Gong Y, Liu X, et al. Serum uric acid and impaired glucose tolerance: The Cardiometabolic Risk in Chinese (CRC) Study, Cell Biochemistry and Biophysics. 2015; 73:1:155-162. https://doi.org/10.1007/s12013-015-0597-5 PMid:25707501
  5. Rathmann W, Hauner H, Dannehl K, Gries FA. Association of elevated serum uric acid with coronary heart disease in diabetes mellitus. Diabetes Metabolisme. 1993; 19:1-2:159-166.
  6. Hovind P, Rossing P, Johnson RJ, Parving HH. Serum uric acid as a new player in the development of diabetic nephropathy. Journal of Renal Nutrition. 2011; 21(1):124-7.
  7. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome—a new world-wide definition. A consensus statement from the international diabetes federation. Diabetic medicine 2006; 23:469-80.
  8. Poulsen P, Kyvik KO, Vaag A. Heritability of type 2 (non-insulin dependent) diabetes mellitus and abnormal glucose tolerance—a population-based twin study. Diabetologia 1999; 42:125–127.
  9. Rich SS. Mapping genes in diabetes: genetic epidemiological perspective. Diabetes 1990;39:1315– 1319.
  10. Cook JT, Shields DC, Page RC, et al. Segregation analysis of NIDDM in Caucasian families, Diabetologia 1994; 37:1231–1240.
  11. Perley MJ, Kipnis DM. Plasma insulin responses to oral and intravenous glucose: studies in normal and diabetic subjects. J Clin Invest 1967; 46:1954– 1962.
  12. Wei F, Chang B, Yang X, Wang Y, Chen L, Li WD. Serum uric acid levels were dynamically coupled with hemoglobin A1c in the development of type 2 diabetes. Scientific reports. 2016; 6:28549. https://doi.org/10.1038/srep28549 PMid:27328642 PMCid:PMC4916504
  13. Babikr WG, Elhussein AB, Abdelraheem A, Magzoub A, Mohamed H, Alasmary M. The Correlation of Uric Acid Levels with Glycemic Control in Type II Diabetic Patients. Biomedical and Pharmacology Journal. 2016; 9(3):1005-8.
  14. Rusdiana, Sri Suryani Widjaja, Muhammad Syahputra, Maya Savira: Association between Haemoglobin A1c and Uric Acid Levels among Patients with Diabetes Mellitus Type 2 at a Primary Health Care Clinic in North Sumatera, Indonesia :Macedonian Journal of Medical Sciences. 2018 Sep 25; 6(9):1633-1635
  15. Akshay Shirsath, Virendra C Patil, Makarand Mane, Shilpa Patil: A Study of Serum Uric Acid Levels in Type 2 Diabetes Mellitus Subjects: A Cross Sectional Study: International Journal of Contemporary Medical Research :January 2019 : Volume 6 , Issue 1 ,pg A21-24.

Corresponding Author

Dr Vibha Sushilendu

Senior Resident, Dept of Biochemistry, IGIMS, Patna