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Category: Volume 07 Issue 12 December 2019
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Title: An Observational Study on Effect of Dengue Fever on Liver Function in Patients Admitted to a Tertiary Care Centre in Rural South Kerala

Authors: Dr H Poornima, Dr Giri Vishnu

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.42

Abstract

Background

Dengue is an important mosquito borne disease in the tropical and subtropical countries. It is often self limited and presents with arthralgia, myalgia, head ache and fever. Though not a hepatotropic virus, liver injury is not un common in dengue infection(1). The degree of liver dysfunction varies from mild to severe.(2,3) The exact mechanism of the liver dysfunction is not known, but is postulated to be either a direct effect of the virus or a dysregulated host immune response(2).  

The present study aims at finding the effects of dengue virus on the liver function and its effect on the severity and outcome of the disease in patients admitted in a tertiary care centre in south Kerala.

Aims and Objectives

  1. To study the pattern of liver function abnormalities in patients admitted with dengue.
  2. To study the effects of liver function abnormality on the severity and the outcome of dengue.

References

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  9. Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayaorn S, Kunentrasai N, Viramitrachai W, Ratanachueke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis. 1997; 176(2):313-321
  10. Wahid SF, Sansui S, Zawawi MM, Ali RA. A comparison of the pattern of liver involvement in dengue hemorrhagic fever. South east asian J Trop Med Public Health. 2000; 31(2): 259-263.
  11. Nguyen TL, Nguyen NT, Tieu NT. The impact of dengue fever on liver function. Res Virol. 1997; 148(4): 273-277.

Corresponding Author

Dr Giri Vishnu G

Vishnugiri (H), Peroor PO, Kottayam, Kerala State, Pin 686637, India