Details
Category: Volume 07 Issue 12 December 2019
Hits: 1061

Title: Infantile Hypertrophic Pyloric Stenosis, A Mendelian Inheritance or Multifactorial Influence: A Case Report

Authors: Dr Vipan Garg, Dr Amar Thakur, Dr Mohit Bajaj, Dr Swati Mahajan, Dr Anju Bala, Dr Amit Kumar

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.25

Abstract

Background: Infantile hypertrophic pyloric stenosis (IHPS) is one of the surgical causes of “protracted vomiting in early infancy”. This condition is characterized by abnormal thickening of the muscular wall of the pylorus, hence it is the commonest cause of gastric outlet obstruction in infant. Males (especially first-borns) are affected approximately 4 to 6 times as often as females. The offspring of a mother and, to a lesser extent, the father who had pyloric stenosisare at higher risk for pyloric stenosis and it develops in approximately 20% of the male and 10% of the female descendants of a mother who had pyloric stenosis. The incidence of pyloric stenosis has been found more in B and O blood groups. Pyloric stenosis is usually presents at 3-4 weeks of life and is more concordant in monozygotic.

Keywords: Pyloric stenosis, newborn.

References

  1. Krogh C, Fischer TK, Skotte L, et al. Familial aggregation and heritability of pyloric stenosis. JAMA 2010;303:2393–9.
  2. Michel LE, Risch N. The genetics of infantile hypertrophic pyloric stenosis: a reanalysis. Am J Dis Child 1993;147:1203–11.
  3. Carter CO, Evans KA. Inheritance of congenital pyloric stenosis. J Med Genet 1969;6:233–54.
  4. Mac Mohan B. The continuing enigma of pyloric stenosis of infancy: a review. Epidemiology 2006;17:195–201. Page 4 of 7 Revised June 2011 Page 5 of 6.
  5. Persson S, Ekborn A, Granath F, et al. Parallel incidences of sudden infant death syndrome and infantile hypertrophic pyloric stenosis: a common cause? Pediatrics 2001;108:E70.
  6. Schechter R, Torfs CP, Batenson TF. The epidemiology of infantile hypertrophic pyloric stenosis. Paediatr Perinat Epidemiol 1997;11:407–27.
  7. Sharma M, Jain SK, Pathania OP, et al. Clin Pediatr 1990;29:566–8.
  8. O’Keeffe FN, Stansberry SD, Swischuk LE, et al. Antropyloric muscle thickness at US in infants: what is normal? Radiology 1991;178:827–30. 2 Kundal VK, et al. BMJ Case Rep 2013. doi:10.1136/bcr-2013-008779 Findings that shed new light on the possible pathogenesis of a disease or an adverse effect
  9. Carter CO. The inheritance of congenital pyloric stenosis. Br Med Bull 1961;17:251–4.
  10. Mitchell LE, Risch N. The genetics of infantile hypertrophic pyloric stenosis. A reanalysis. Am J Dis Child 1993;147:1203–11.
  11. Capon F, Reece A, Ravinderarajah R, et al. Linkage of monogenic infantile hypertrophic stenosis to chromosome16p 12- p13 and evidence for genetic heterogeneity. Am J Hum Genet 2006;79:378–82.
  12. Kidd KK, Spence MA. Genetic analysis of pyloric stenosis suggesting a specific maternal effect. J Med Genet 1976;13:290–4.
  13. Sorenson HT, Norgard B, Pedersen L, et al. Maternal smoking and risk of hypertrophic infantile pyloric stenosis: 10 year population based cohort study. Br Med J 2002;325:1011–12.
  14. Bianca S, Ingegnosi C, Barbagallo MA, et al. Sex ratio imbalance and birth weight in newborns with isolated hypertrophic pyloric stenosis. J Obstet Gynaecol 2003;23:43.
  15. Hernanz-Schulman M, Lowe LH, Johnson J, et al. In vivo visualization of pyloric mucosal hypertrophy in infants with hypertrophic pyloric stenosis: is there an etiologic role? AJR Am J Roentgenol 2001;177:843–8.
  16. Paulozzi LJ. Is Helicobacter pylori a cause of infantile pyloric stenosis? Med Hypotheses 2000;55:119–25.
  17. Peled N, Dagan O, Babyn P, et al. Gastricoutlet obstruction induced by prostaglandins therapy in neonates. N Engl J Med 1992;327:505–10.
  18. Krogh C, Biggar RJ, Fischer TK, et al. Bottle-feeding and the risk of pyloric stenosis.

Corresponding Author

Dr Amar Thakur

Junior Resident, Department of Pediatrics, DR RPGMC Tanda