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Category: Volume 07 Issue 12 December 2019
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Title: Comparison of statin-induced myalgia between atorvastatin and rosuvastatin and among different duration of treatment groups: An observational study in a tertiary care hospital of West Bengal

Authors: Prof. Abhijit Das, Samya Dutta, Prof. Suhrita Paul, Arpita Maitra, Shouvik Choudhury

 DOI: https://dx.doi.org/10.18535/jmscr/v7i12.22

Abstract

Introduction

Coronary heart disease (CHD) is a leading cause of cardiovascular morbidity and mortality worldwide.1Even in India, a recent surge has been noticed in the prevalence of CHD (from 10.19% in 1991-94 to 13.91% in 2010-12).2The mainstay of pathogenesis of CHD fundamentally involves building up of atherosclerotic plaques inside the arterial wall which leads to narrowing of the arterial lumen and finally, diminished blood flow. The development of cholesterol plaques in the arterial walls has conventionally been linked to dyslipidemia.3-7 Dyslipidemia is defined as irregularities in plasma concentration of cholesterol lipoprotein lipids, such as an elevated total cholesterol or increased low-density lipoprotein (LDL) or decreased concentration of high-density lipoprotein (HDL). Recent population based studies in India documented an increase in the prevalence of dyslipidemia in either gender and across all inhabitations and socio-economic strata.8-11 Consequently, a significant portion of the Indian population faces a high risk of developing atherosclerosis and as a result, the incidence of cardiovascular morbidities may flare up in our country in the forthcoming years.12

3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) have always remained the mainstay of pharmacotherapy for preventing atherosclerotic changes in the coronary arterial walls, unless found absolutely contraindicated in certain cases. Thus, their efficacy has been proved in primary and secondary prevention of cardiovascular diseases in several studies.13-15

References

  1. Ardeshna DR, Bob-Manuel T, Nanda A, Sharma A, Paul W, Skelton M. Asian-Indians: a review of coronary artery disease in this understudied cohort in the United States. Ann Transl Med. 2018;6:1-12.
  2. Praveen PA, Roy A, Anand K, Lakshmy R, Ruby G, Shah Bet al. Rising prevalence of coronary heart disease (CHD) in urban Delhi, India-results from a repeat cross-sectional study. Eur Heart J. 2013;34(abstract suppl):470.
  3. Emerging Risk Factors Collaboration, Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009 Nov 11;302(18):1993-2000.
  4. Prospective Studies Collaboration, Lewington S, Whitlock G, Clarke R, Sherliker P, Emberson J et al. Blood cholesterol and vascular mortality by age, sex, and blood pressure: a metaanalysis of individual data from 61 prospective studies with 55,000 vascular deaths. Lancet. 2007;370:1829–39.
  5. Gupta S, Gudapati R, Gaurav K, Bhise M. Emerging risk factors for cardiovascular diseases: Indian context. Indian J Endocrinol Metab. 2013 Sep-Oct; 17(5): 806–14.
  6. Gupta R, Gupta R, Guptha S, Sharma KK, Gupta A, Deedwania PC. Regional variations in cardiovascular risk factors in India: India Heart Watch. World J Cardiol. 2012;4:112–20.
  7. Sinha RP, Tewari S, Kumar S, Kapoor A, Garg N, Goel PK et al.Comprehensive Lipid Tetrad Index and Lipoprotein(a) as a Marker for Coronary Artery Disease.Indian Heart J 2005; 57: 381–425.
  8. Gupta R, Rao RS, Misra A, Sharma SK. Recent Trends in Epidemiology of Dyslipidemias in India. Indian Heart J. 2017;69:382-92.
  9. Gupta R, Sharma M, Goyal NK, Bansal P, Lodha S, Sharma KK. Gender differences in seven-year trends in cholesterol lipoproteins and lipids: insights from a hospital database in India. Indian J Endocrinol Metab. 2016;20:211–8.
  10. Gupta R, Sharma KK, Gupta BK, Gupta A, Saboo B, Maheshwari A et al. Geographic epidemiology of cardiometabolic risk factors in urban middle-class residents in India: a cross sectional study. J Global Health. 2015;5:10411.
  11. Gupta R, Gupta KD. Coronary heart disease in low socioeconomic status subjects in India: an evolving epidemic. Indian Heart J. 2009;61:358–67.
  12. Prabhakaran D, Jeemon P, roy A. Cardiovascular Diseases in India Current Epidemiology and Future Directions. Circulation. 2016;133:1605–20.
  13. Catapano AL, Farnier M, Foody JM, Toth PP, Tomassini JE, Brudi P et al.Combination therapy in dyslipidemia: where are we now?2014 Nov;237(1):319-35.
  14. Joy TR, Hegele RA. Narrative Review: Statin-Related Myopathy. Ann Intern Med. 2009;150:858-68.
  15. Joy TR, Monjed A, Guang YZ, Hegele RA, McDonald CG, Mahon JL. N-of-1 (Single Patient) Trials for Statin-Related Myalgia. Ann Intern Med. 2014;160:301-10.
  16. Sewright KA, Clarkson PM, Thompson PD. Statin Myopathy: Incidence, Risk Factors, and Pathophysiology. Current Atherosclerosis Reports. 2007;9:389–96.
  17. Sathavism S. Statin induced myotoxicity. E J Intern Med. 2012;23:317-24.
  18. Urso ML, Clarkson PM, Hittel D, Hoffman EP, Thompson PD. Changes in ubiquitin proteasome pathway gene expression in skeletal muscle with exercise and statins. Arterioscler Thromb Vasc Biol 2005, 25:2560–6.
  19. Jacobson TA. Statin safety. Lessons from new drug applications for marketed statins. Am J Cardiol 2006, 97(8A):44C–51C.
  20. Thompson PD, Clarkson P, Karas RH. Statin-associated myopathy. JAMA 2003, 289:1681–90.
  21. Kashani A, Phillips CO, Foody JM, Wang Y, Mangalmurti S, Ko DT et al. Risks associated with statin therapy: a systematic overview of randomized clinical trials. Circulation 2006, 114:2788–97.
  22. Thavendiranathan P, Bagai A, Brookhart MA, Choudhry NK. Primary prevention of cardiovascular diseases with statin therapy: a meta-analysis of randomized controlled trials. Arch Intern Med 2006, 166:2307–13.
  23. Hansen KE, Hildebrand JP, Ferguson EE, Stein JH: Outcomes in 45 patients with statin-associated myopathy. Arch Intern Med 2005, 165:2671–6.
  24. Talbert RL. Safety issues with statin therapy. J Am Pharm Assoc 2006, 46:479–88.
  25. Pasternak RC, Smith SC Jr, Bairey-Merz CN, Grundy SM, Cleeman JI, Lenfant C, American College of Cardiology. ACC/AHA/NHLBI clinical advisory on the use and safety of statins. J Am Coll Cardiol. 2002;40:567-72.
  26. Bays H. Statin safety: an overview and assessment of the data—2005. Am J Cardiol. 2006;97:6C-26C.
  27. Law M, Rudnicka AR. Statin safety: a systematic review. Am J Cardiol. 2006; 97:52C-60C.
  28. Collins R, Reith C, Emberson J, Armitage J, Baignet C, Blackwell L et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet. 2016; 388: 2532–6.
  29. Parker BA, Capizzi JA, Grimaldi AS, Clarkson PM, Cole SM, Keadle J et al. Effect of statins on skeletal muscle function. Circulation 2013; 127: 96–103.
  30. Berne C, Siweret-Delle A. Comparison of rosuvastatin and atorvastatin for lipid lowering in patients with type 2 diabetes mellitus: results from the URANUS study. Cardiovasc Diabetol. 2005; 4: 7.

Corresponding Author

Samya Dutta

Post Graduate Trainee, Department of Pharmacology, Burdwan Medical College, West Bengal