Title: An Atypical Case of OSSN
Authors: Dr Arti Sareen1, Dr Kusum Bhanoo
DOI: https://dx.doi.org/10.18535/jmscr/v7i12.07
Abstract
The term Ocular Surface Squamous Neoplasia (OSSN) encompasses a rare spectrum of diseases of the conjunctiva or the cornea which ranges from squamous papilloma to mild dysplasia to carcinoma in situ to invasive squamous cell carcinoma. It is mainly a diagnosis of clinical suspicion. We here present a case of OSSN in a young female who presented to us with a six months history or mass in her left eye with irritation and redness and who was put on topical interferons based on clinical suspicion to which she showed little response. She was then taken up for excisional biopsy, the histopathology reports of which confirmed the diagnosis of OSSN.
References
- Coroi MC, Rosca E, Mutui G, Coroi T. Squamous carcinoma of the conjunctiva. Rom J Morphol Embryol 2011;52(1):513-515.
- Lee GA, Girst W. Ocualr surface squamous neoplasia. SurvOphthalmol 1995;39(6):429-450.
- Birkholz ES, Goins KM, Sutphin JE, Kitzmann AS, Wagoner MD. Treatment of ocular squamous cell intraepithelial neoplasia with and without mitomycin C. Cornea 2011;30(1):37-41.
- Newton R. A review of the aetiology of squamous cell carcinoma of the conjunctiva. British Journal of Cancer1996; 74:1511-1513.
- Mahomed A, Chetty R. Human immunodeficiency virus infection, Bci-2, p53 protein, and Ki-67analysis in OSSN. Arch Ophthalmol 2002; 120:554-8.
- Lee GA, Williams G, Hirst LW, Green AC. Risk factors in the development of ocular surface epithelial dysplasia. Ophthalmology 1994;101: 360-64.
- Karp CL, Scott IU, Chang TS, et al. Conjunctival intraepithelial neoplasia:a possible marker for human immunodeficiency virus infection. Arch Ophthalmol 1996; 114:257-61.
- Papaioannou IT, Melachrinou MP, Drimtzias EG, Gartaganis SP. Corneal -conjunctival squamous cell carcinoma. Cornea 2008;27(8):957-8.
- Sethi HS, NaikMayuresh, Joshi Mukesh, Gupta VS. Ocular Surface Squamous Neoplasia. DOS Times; 20(6): 65-70.