Title: The Milan System for Reporting Salivary Gland Cytopathology (MSRSGC)

Authors: Dr Sumana Sindhuram V, Dr Roopashree G, Dr Bharathi M

 DOI: https://dx.doi.org/10.18535/jmscr/v7i11.170

Abstract

Background: FNA is a cost-effective and minimally invasive diagnostic tool for sampling salivary gland lesions. However due to intra-tumoral heterogeneity and frequent overlapping of cyto-morphologic features precise subtyping of neoplasms can be challenging. To address this, International panel of experts under the joint effort of the American society of cytopathology and the International academy of cytology developed the MSRSGC.

Methodology: 356 salivary gland FNA samples were retrospectively analysed and re-categorised into 6 categories of the Milan system. Histopathology diagnoses were retrieved wherever available. Overall ROM were calculated for each category.

Results: On re-categorising into the Milan system, 62 cases were assigned to non-diagnostic category (17.4%), 67 to non-neoplastic category (18.8%), 48 as Atypical (13.5%), 101 as benign neoplasms (28.4%), 35 to the salivary gland neoplasm of uncertain malignant potential  (9.8%), 16 as suspicious for malignancy (4.5%) and 27 to the malignant category (7.6%).The ROM for above mentioned category were 30%, 7.1%, 14.2%, 3%, 31%, 67% and 95.2% respectively.

Conclusion: MSRSGC provides uniform reporting system for salivary gland cytopathology which helps to reduce reporting ambiguities and thus improves overall patient care.

Keywords:  Fine-needle aspiration; Milan system for reporting salivary gland cytopathology (MSRSGC); Risk of malignancy (ROM).

References

  1. Seethala RR, Li Volsi VA, Baloch ZW. Relative accuracy of fine needle aspiration and frozen section in the diagnosis of lesions of the parotid gland. Head Neck.2005;27:217-223.
  2. Viswanathan K, Sung S et al. The role of the Milan System for Reporting Salivary Gland Cytopathology: a 5-year institutional experience [published online ahead of print May 24, 2018].
  3. Wang H, Fundakowski C, Khurana JS, Jhala N. Fine-needle aspiration biopsy of salivary gland lesions. Arch Pathol Lab Med. 2015; 139:1491-1497.
  4. Goyal S, Sharma S, Diwaker P. Diagnostic role and limitations of FNAC in oral and jaw swellings. Diagn Cytopathol.2015; 43:810-818.
  5. Fakhry N, Antonini F, Michel J, et al. Fine-needle aspiration cytology in the management of parotid masses: evaluation of 249 patients. Eur Ann Otorhinolaryngol Head Neck Dis.2012;129:131-135.
  6. Layfield LJ, Glasgow BJ. Diagnosis of salivary gland tumors by fine-needle aspiration cytology: a review of clinical utility and pitfalls. Diagn Cytopathol. 1991;7:267-272.
  7. Kocjan G, Nayagam M, Harris M. Fine needle aspiration cytology of salivary gland lesions: advantages and pitfalls. Cytopathology.1990;1:269-275.
  8. Jayaram N, Ashim D, Rajwanshi A, Radhika S, Banerjee CK. The value of fine-needle aspiration biopsy in the cytodiagnosis of salivary gland lesions. Diagn Cytopathol.1989;5:349-354.
  9. Mondal A, Das MM, Mukherjee PK. Fine needle aspiration biopsy cytology in diagnosis of salivary gland tumours. J Indian Med Assoc. 1989;87:108-110.
  10. Schmidt RL, Hall BJ, Wilson AR, Layfield LJ. A systematic review and meta-analysis of the diagnostic accuracy of fine-needle aspiration cytology for parotid gland lesions. Am J ClinPathol. 2011;136(1): 45-59.
  11. Layfield LJ. Fine-needle aspiration in the diagnosis of head and neck lesions: a review and discussion of problems in differential diagnosis. Diagn Cytopathol. 2007;35 (12): 798-805.
  12. Layfield LJ, Gopez E, Hirschowitz S. Cost efficiency analysis for fineneedle aspiration in the workup of parotid and submandibular gland nodules. Diagn Cytopathol. 2006;34(11):734-738.
  13. Liu CC, Jethwa AR, Khariwala SS, Johnson J, Sensitivity SJJ. Specificity, and posttest probability of parotid fine-needle aspiration: a systematic review and meta-analysis. Otolaryngol Head Neck Surg. 2016; 154(1):9-23.
  14. Rossi ED, Faquin WC, Baloch Z, et al. The Milan System for Reporting Salivary Gland Cytopathology: Analysis and suggestions of initial survey. Cancer Cytopathol 2017;125(10):757-766.
  15. Song JS, Shafique K, Wong QL, LiVolsi AV, Montone TK, Baloch Z. The utility of the Milan system as a risk stratification tool for salivary gland fine needle aspiration cytology specimens. Clinical cytojan 2019 [Epub ahead of print]
  16. Ali SZ, Cibas E,eds. The Bethesda System for Reporting Thyroid Cytopathology: Definitions, Criteria and Explanatory Notes. 1sted. New York: Springer US; 2010.
  17. Jain R, Gupta R, Kudesia M, Singh S. Fine needle aspiration cytology in diagnosis of salivary gland lesions: A study with histologic comparison. Cyto Journal 2013;10:5.
  18. Schindler S, Nayar R, Dutra J, Bedrossian CW. Diagnostic challenges in aspiration cytology of the salivary glands. Semin Diagn Pathol 2001;18(2):124-146.
  19. Ashraf A, Shaikh AS, Kamal F, Sarfraz R, Bukhari MH. Diagnostic reliability of FNAC for salivary gland swellings: a comparative study. Diagn Cytopathol 2010;38(7):499-504.
  20. Layfield LJ, Tan P, Glasgow BJ. Fine-needle aspiration of salivary gland lesions. Comparison with frozen sections and histologic findings. Arch Pathol Lab Med. 1987;111:346-353.
  21. Behzatoglu K, Bahadir B, Kaplan HH, Yucel Z, Durak H, Bozkurt ER. Fine needle aspiration biopsy of the parotid gland. Diagnostic problems and 2 uncommon cases. Acta Cytol. 2004; 48:149-154.
  22. Mukunyadzi P. Review of fine-needle aspiration cytology of salivary gland neoplasms, with emphasis on differential diagnosis. Am J ClinPathol. 2002;118 (suppl): S100-S115.
  23. Boccato P, Altavilla G, Blandamura S. Fine needle aspiration biopsy of salivary gland lesions. A reappraisal of pitfalls and problems. ActaCytol. 1998;42:888-898.
  24. Cajulis RS, Gokaslan ST, Yu GH, Frias-Hidvegi D. Fine needle aspiration biopsy of the salivary glands. A five-year experience with emphasis on diagnostic pitfalls. ActaCytol. 1997;41:14121420.
  25. Cardillo MR. Salivary gland masses: the diagnostic value of fineneedle aspiration cytology. Arch Anat Cytol Pathol. 1990;38: 26-32.
  26. Thiryayi SA, Low YX, Shelton D, Narine N, Slater D, Rana DN. A retrospective 3-year study of salivary gland FNAC with categorisation using the Milan reporting system. Cytopathol 2018. [Epub ahead of print]
  27. Pusztaszeri M, Baloch Z, Vielh P, Faquin WC. Application of the Milan system for reporting risk stratification in salivary gland cytopathology. Cancer Cytopathol 2018;126 (1):69-70.
  28. Salehi S, Maleki Z. Diagnostic challenges and problem cases in salivary gland cytology: A 20-year experience. Cancer Cytopathol 2018;126(2):101-111.
  29. Hughes JH, Volk EE, Wilbur DC, Cytopathology Resource Committee CoAP. Pitfalls in salivary gland fine-needle aspiration cytology: lessons from the College of American Pathologists Interlaboratory Comparison Program in Nongynecologic Cytology. Arch Pathol Lab Med 2005;129(1):26-31.
  30. Maleki Z, Miller JA, Arab SE, et al. "Suspicious" salivary gland FNA: Risk of malignancy and interinstitutional variability. Cancer Cytopathol 2018;126 (2):94-100.
  31. Rossi ED, Wong LQ, Bizzarro T, et al. The impact of FNAC in the management of salivary gland lesions: Institutional experiences leading to a risk-based classification scheme. Cancer Cytopathol 2016;124(6):388-396.
  32. Layfield LJ, Baloch Z, Hirschowitz SL, Rossi ED. Impact on Clinical Follow-up of the Milan System for Salivary Gland Cytology: A Comparison with a Traditional Diagnostic Classification. Cytopathol 2018. [Epub ahead of print]

Corresponding Author

Dr Roopashree G

Postgraduate Student, Department of Pathology, Mysore Medical College and Research Centre, Mysore