Title: A Clinicopathological Study of Pre and Post Menopausal Breast Cancer Patients in North Bengal Population & Their Correlation with Estrogen and Progesterone Receptor Status
Authors: Dr Suparna Banerjee, Dr Rajat Bandyopadhyay
DOI: https://dx.doi.org/10.18535/jmscr/v7i11.156
Abstract
Breast cancer is the commonest cancer among Indian females. Tumour size, lymph node, grade, vascular invasion, Estrogen receptor Progesterone receptor (ER PR) and HER2neu receptor expression are important both prognostically and in deciding therapy.
Materials and Methods: 52 operated breast cancer patients of North Bengal region with complete history and staging were studied. Clinical profile (menopausal status, tumour size, stage, lymph nodes), pathologic findings (histological type, grade, skin/nipple areola involvement, LVI, perineural spread, lymph node status) and ER PR status were correlated.
Results: Most patients presented at late stage with more than 5 cm tumour often with lymph node metastasis. Commonest age group was 45-54 years, majority were postmenopausal and most tumours were histological grade 2. Positive ER/PR status was observed in 57.69% cases and ER/PR status correlated significantly with clinicopathological parameters.
Keywords: Breast cancer, Clinicopathological parameters, ER PR status.
References
- Malvia S, Bagadi SA, Dubey US2, Saxena S. Epidemiology of breast cancer in Indian women. Asia Pac J Clin Oncol. 2017; 13: 289–295
- Sepideh Siadati, Majid Sharbatdaran, Novin Nikbaksh, Naser Ghaimean. Correlation of ER, PR and HER-2/Neu with other Prognostic Factors in Infiltrating Ductal Carcinoma of Breast (4):289-295. Iran J Pathol 2015 Summer; 10(3): 221–226.
- Iqbal BM, Buch A. Hormone receptor (ER, PR, HER2/neu) status and proliferation index marker (Ki-67) in breast cancers: Their onco-pathological correlation, shortcomings and future trends. Med J DY Patil Univ 2016; 9:674-9
- Payne JS, Bowen RL et al. Predictive markers in breast cancer--the present. Histopathology 2008 Jan;52(1):82-90.
- Mohsin SK1, Weiss H 3et al. Progesterone receptor by immunohistochemistry and clinical outcome in breast cancer: a validation study. Mod Pathol.2004 Dec;17(12)
- Rashmi Patnayak, Amitabh Jena et al. Hormone receptor status (estrogen receptor, progesterone receptor), human epidermal growth factor-2 and p53 in South Indian breast cancer patients: A tertiary care center experience. Indian J Med Paediatr Oncol. 2015 Apr-Jun; 36(2): 117–122.
- Dunnwald, L.K., Rossing, M.A. & Li, C.I. Hormone receptor status, tumor characteristics, and prognosis: a prospective cohort of breast cancer patients. Breast Cancer Res 9, R6 (2007) 2000 Oct;9(5):267-70; discussion 270.
- Shet T, Agrawal A, Nadkarni M ret al. Hormone receptors over the last 8 years in a cancer referral center in India: What was and what is?. Indian J Pathol Microbiol [serial online] 2009; 52:171-4.
- National Cancer Registry Programme: Consolidated Report of the Population Based Cancer Registries 1990-1996. Consolidated Report of the population-based cancer registries 1990-1996. ICMR, New Delhi, 2001.
- Ur Rahman, A. Shaharyar, M. Hafeez, and A. W. Goraya. Relationship of ER, PR, and HER2-neu status with age, menopausal status, and axillary nodal status in early breast cancer. Journal of Clinical Oncology 2011 29:15_suppl, e11011-e11011.
- Kakarala M, Rozek L, Cote M, Liyanage S, Brenner DE. Breast cancer histology and receptor status characterization in Asian Indian and Pakistani women in the U.S.--a SEER analysis. BMC Cancer. 2010; 10:191. Published 2010 May 11. doi:10.1186/1471-2407-10-191.
- Shrigondekar P, Desai S, Bhosale S, Mankar D, Badwe A. Study of Hormone Receptor Status of Breast Carcinoma and Its Correlation with the Established Prognostic Markers.
- Desai SB1, Moonim MT, Gill AK, Punia RS, Naresh KN, Chinoy RF. Hormone receptor status of breast cancer in India: a study of 798 tumours. Breast. 2000 Oct;9(5):267-70; discussion 270.
- Dutta V, Chopra GS et al. Hormone Receptors, Her-2/Neu and Chromosomal Aberrations in Breast Cancer. Medical Journal Armed Forces India 64(1):11-15 · January 2008. Article in Medical Journal Armed Forces India 64(1):11-15 · January 2008.