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Category: Volume 07 Issue 11 November 2019
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Title: Study of Platelet Indices in Ischemic Stroke Patients

Authors: Dr J. Punekar, Dr Brijraj Shukla

 DOI: https://dx.doi.org/10.18535/jmscr/v7i11.42

Abstract

Introduction: Cerebrovascular diseases are one of the most general causes of morbidity and mortality.  Ischemic stroke occurs when blood flow in a vessel is compromised by atherosclerosis plagues and it ultimately leads to thrombus formation. Platelets plays an essential role in the pathophysiology of ischemic stroke by developing intravascular thrombus after erosion or rupture of atherosclerotic plaques. The involvement of blood clot in ischemic stroke demands for effective and constant monitoring of haemostatic parameters such as platelet components in stroke patients in order to properly manage and treat them.

Methods & Material: Considering the best availability of the patients by reviewing the previous records of this health facility to achieve the maximum sample size we randomly screen all patients who have fulfill the inclusion and exclusion criteria and ready to give the written consent. After all aseptic precautions 2ml of blood sample was obtained from antecubital vein of the patient within 48 hours of onset of signs and symptoms of ischemic stroke. Samples were collected in EDTA vials, kept at room temperature. The printout reports of samples fed to MINDRAY-BC 3600 Autoanalyser and collected and analyzed.

Results: There was direct relationship of MPV, PC and PLCR with severity of ischemic stroke and inverse relationship of PDW and PCT with severity of ischemic stroke. PC and PLCR were higher in patient with ischemic stroke but PC showed not significant change whereas PLCR showed significant abnormal changes in ischemic stroke patient.                                                 

Conclusions: Platelet indices are marker of platelet function. Its utility as a risk factor in cases of coronary artery disease is well known. This study shows that MPV is higher in patients of acute ischemic stroke / TIA, hence, it can be regarded as an independent risk factor for ischemic stroke / TIA. Elevated mean platelet volume is associated with more severe morbidity and worse outcome in patients with acute ischemic stroke / TIA. There was direct relationship of MPV, PC and PLCR with severity of ischemic stroke and inverse relationship of PDW and PCT with severity of ischemic stroke.

References

  1. Neki NS, Minda N, Jain A. A study of association of mean platelet volume and ischemic stroke. Asian Pac. J. Health Sci, 2016; 3(4): 212-219
  2. Donnan, G et al. Stroke. Lancet, 2008; 371: 1612-1623
  3. Al Tameemi WF. Significance of platelet indices in patients with acute ischemic stroke. Iraqi J Med Sci, 2012; 10(4): 383-389
  4. Gideon CS, Ighida BF, Mgheoma EE. Changes in haematological parameters in stroke patients in port Harcourt, Nigeria. IJSR, 2016; 5(3): 912- 915
  5. Elsayed A, et al. Mean platelet volume and mean platelet volume/ platelet count ratio as a risk stratification tool in the assessment of severity of acute ischemic stroke. Alexandria Journal of Medicine, 2017; 53: 67-70
  6. Sridharan M, et al. A prospective study of mean platelet volume in predicting stroke type and its severity. JMSCR, 2018; 6(3): 333-337
  7. Arevalo-Lorido JC, et al. Mean platelet volume in acute phase of ischemic stroke, as predictor of mortality and functional outcome after 1 year. Journal of stroke and cerebrovascular diseases, 2013; 22(4):297-303
  8. Greisenegger S et al. Is elevated mean platelet volume associated with a worse outcome in patient with acute ischemic cerebrovascular events. Stroke,2004; 35: 1688-1691
  9. Muralidharan K, Murugesan S, et al. A study of mean platelet volume levels in patients with ischemic stroke. J. Evid. Based Med. Healthc, 2016; 3(71): 3874-3877
  10. Ghahremanfard F, et al. The relationship between mean platelet volume and severity of acute ischemic brain stroke. Neurosciences, 2013; 18(2):147-51
  11. Mayda- Domac F, et al. Prognostic role of mean platelet volume and platelet count in ischemic and hemorrhagic stroke. Journal of stroke and cerebrovascular diseases, 2010; 19(1): 66-72
  12. Mathur V, et al. A study on association of mean platelet volume and ischemic stroke. IOSR-JDMS, 2018; 17(4):35-46

Corresponding Author

Dr J. Punekar

Department of Medicine, Netaji Subhash Chandra Bose Medical College, Jabalpur, (M.P)