Title: Study of serum Aminotransfersase levels in dengue fever and its correlation
Authors: Dr Balakumar.J, Prof. Dr S. Balasubramaniyan.M.D., Dr N.Paari M.D.
DOI: https://dx.doi.org/10.18535/jmscr/v7i11.07
Abstract
Background: Dengue fever is the most prevalent arthropod borne viral illness in humans caused by dengue virus. The involvement of liver in dengue fever is not uncommon. Liver involvement in dengue fever is manifested by the elevation of transaminases due to direct attack of virus itself or the use of hepatotoxic drugs.1
Aim and Objective: to assess the serum aminotransferase level in patient with dengue fever and to correlate serum aminotransferase level and severity of dengue fever.
Methods: This is a prospective observational study conducted from November 2017 to October 2019. A total of 50 fever patients admitted with positive dengue serology in Medicial ward, RMMCH were included after satisfying the inclusion and exclusion criteria. All the patients were subjected to complete history taking and clinical examination. Investigations like complete blood count, liver function test, dengue serology and abdominal ultrasound were done in all patients.
Result: A total of 50 dengue serology positive patient were included in the study. Among them there were 27 (54%) males and 24(46%) females. In our study 41 patients (82%) had elevated serum transaminase level, Mean AST level was 134.84 IU/L and the mean ALT level was 107.88 IU/L. The level of AST is higher when compared to ALT in most of the patients. Among those who had elevated aminotransferase level 12 patients (24%) had both elevated aminotransferase level and free fluid in the abdomen. Out of 50 patients 32 (64%) had reduced platelet count (less than one lakh) and all the 32 patients had elevated serum aminotransferase level. There was significant negative correlation between serum aminotransferase level and platelet count (P value < 0.001)
Conclusion: Hepatic dysfunction is very common in all forms of Dengue infection. Serum Aminotransferase level correlate with severity of Dengue fever. Aspartate Aminotransferase was significantly raised when compared to Alanine Aminotransferase in most of the patients.
Keywords: Dengue fever, Serum Aminotransferase, Aspartate Aminotransferase.
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