Title: Assessment of Urine Protein & Urine Creatinine in severe acute stroke patients with complications of type-2 diabetes and hypertension
Authors: Dr Rakesh Meena, Dr Gajraj Singh Yadav, Dr Gajender Singh Meena
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.150
Abstract
Background: Stroke is a complex stage in patients of uncontrolled type-2 diabetes and hypertensive patients. Urine Protein and Urinary Creatinine may be a predicator in stroke patients? On this view; this study has been carried out.
Objectives: Find out Urine Protein and Urinary Creatinine in the patients of sever acute stroke with complication of type-2 DM and hypertension.
Introduction: Stroke is caused by the interruption of the blood supply to the brain, usually because a blood vessel bursts or is blocked by a clot. This cuts off the supply of oxygen and nutrients, causing damage to the brain tissue. Strokes in diabetic and hypertensive patients are due to occlusion of small paramedial penetrating arteries. It is the third major cause of death after heart disease and cancer in the world.
Material and Methods: The present study comprised 500 Subjects (250 cases and 250 controls). 250 acute stroke patients with diabetes non-hypertensive (N=125) and with hypertension non-diabetic (N=125) recruited from the IPD of NIMS Hospital were selected as cases. 250 healthy age and sex-matched subjects were selected as controls. Adults suffering from Stroke were inclused and surgical patient, pregnant women were excluded. Estimation urinary protein was done by the pyrogallor red colorimetric method. Estimation of urinary creatinine was done by Jaffe’s alkaline picrate method. Statistical analysis was performed using Microsoft Excel 2007. Data was expressed as mean±SD. Individual groups were compared (significance of difference) using Student’s unpaired t-test.
Results: Urine Protein was found elevated at high significant level while Urine Creatinine was not found significant in stroke with complication of type-2 diabetes mellitus and hypertensive subjects.
Conclusion: Our prospective hospital based study gives evidence that beside hypertension and hyperglycemia, Urine Protein may assumed as clinical predicator in patients of severe acute stroke with long duration uncontrolled hypertension and hyperglycemia.
Keywords: Urinary Protein, Urinary Creatinine, Stroke.
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