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Category: Volume 07 Issue 08 August 2019
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Title: Infiltrating Ductal Breast Carcinoma: Correlation of Cytological Grading with Histopathological Grading and regional lymphnode status

Authors: Dr Akkem Vijaya Jyothi, Dr. B Nagaraja

 DOI: https://dx.doi.org/10.18535/jmscr/v7i8.129

Abstract

In the initial evaluation of breast lumps, Fine Needle Aspiration (FNA) is a proven diagnostic technique. Aim of the study is to grade the infiltrating ductal carcinoma of breast by both cytologically and histologically and to correlate its grading. A total of 44 cases with a cytological diagnosis of invasive ductal carcinoma subsequently proved on histology were studied. These were graded according to Robinson’s cytological grading (RCG) and Elston’s modification of Bloom Richardson’s histological grading system. Statistical analysis was done using χ2 test. Multiple regression analysis was done to assess the significance of each cytological and histological parameter. There were 22(50%), 19(43.1%) and 3(6.8%) cases of grade I, II and III ductal carcinomas respectively graded cytologically and 19(43.2%), 20(45.5%) and 5(11.4%) cases of ductal carcinomas graded I, II and III histologically. Overall, in 37 cases (84%) the cytological grade correlated with the histological grade and in 7 cases (18%) discrepancy was noted. There was a significant association (p<0.05) between the cytological and histological grading. This study showed that the extent of cell size, cell uniformity, nucleoli were the most influential features. 68% of grade I tumors 53% of grade II and 100% of grade III tumors showed lymphnode metastasis. Lymph node metastasis was seen irrespective of the grade of the tumor. To conclude grading act as powerful predictor of tumor aggressiveness; should thus be addressed in pathological analysis of breast carcinoma as it is simple and feasible.

Keywords: Breast carcinoma, Cytological grading, Cytohistological correlation, Histological grading.                      

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Corresponding Author

Dr B Nagaraja

Associate Professor, Department of Pathology, Government Medical College, Kadapa, India