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Category: Volume 07 Issue 08 August 2019
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Title: Daily versus intermittent Anti-tuberculous Treatment in Pediatric Tuberculosis: A Comparative Study

Author: Dr Ambika Sood

 DOI: https://dx.doi.org/10.18535/jmscr/v7i8.104

Abstract

Background: The World Health Organization (WHO) declared tuberculosis (TB) a global public health emergency in 1993. It is the second leading cause of death from an infectious disease worldwide and leading cause of ill- health among millions of people. Treatment options of tuberculosis include intermittent therapy in DOTS and daily therapy. Aim of our study is to compare daily versus intermittent antituberculous treatment.

Methods: This observational prospective study was conducted at Indira Gandhi Medical College, Shimla. Detailed information was collected on predesigned proformas and results were compiled and evaluated on master chart.

Results: 460 children were diagnosed with various forms of tuberculosis, out of which 82 children fulfilling the inclusion criteria were enrolled in this study. These were divided into two groups (Group 1 and Group 2). The mean age at the time of enrollment was 10.34 years  42 (53.16%) were males and 37 (46.83%) females, with a sex ratio of M:F=1.1:1. sputum negativity in the daily therapy group showed statistical significance with a p value of < .05, an odds ratio of 0.17 with Confidence Intervals : 0.02 – 0.94.

Conclusion: Tuberculosis remains a major cause of mortality and morbidity in Pediatric population. Daily therapy may be a futuristic treatment option with better results.

Keywords: Tuberculosis Pediatric, Daily, Intermittent, Gastric aspirate.

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Corresponding Author

Dr Ambika Sood

Address: 98, Lower Bazaar, Shimla. Pin-171001, India