Details
Category: Volume 07 Issue 08 August 2019
Hits: 975

Title: Role of Boerhaavia Diffusa L: A In Relief of Neuropathic Pain of Paclitaxel Induced Neuropathy

Authors: Dr Sandeep Kamlekar, Dr Jamila Tahashildar, Dr Sangita Gupta

 DOI: https://dx.doi.org/10.18535/jmscr/v7i8.96

Abstract

Background: The present study was designed to investigate the neuropathic activity of Boerhaavia diffusa L. against Paclitaxel induced peripheral neuropathy in rats.

Materials and Methods: Peripheral neuropathy was induced by a single i.p injection of Paclitaxel 2mg/kg for four alternative days 0, 2,4,6. The ethanolic extract of Boerhaavia diffusa was administered 100, 200, 400 mg/kg, p.o. daily up to 28 days. Neuropathic pain was assessed via various behavioral parameters procedures viz., Eddy’s hot plate test and cold water tail immersion test, pinprick, Acetone drop, photoactometer tests were performed to assess the degree of thermal, mechanical hyperalgesia, cold allodynia along with locomotor activity.

Result: In this study Paclitaxel induced rats showed decreased tail withdrawal latency, and increased paw withdrawal latency along with decreased locomotor activity was observed for various behavioural tests. After treating rats with Boerhaavia diffusa L. at various doses 100, 200, 400 mg/kg, p.o. daily up to 28 days, the animals showed improvement in tail and paw withdrawal latency and locomotor activity in dose dependent manner.

Conclusion: The present study reveals the supplementation of B. diffusa L., extract ameliorates the pacliatxel induced neuropathy via above mentioned actions.

Keywords: Neuropathic pain, Paclitaxel, Boerhaavia diffusa L.

References

  1. Campbell J. Mechanisms of neuropathic pain. Neuron, 2006, 52 (1) : 77-92.
  2. Horowitz SH. The diagnostic workup of patients with neuropathic pain. Medical Clinics of North America, 2007, 91(1) : 21-30.
  3. Jensen TS. Translation of symptoms and signs into mechanisms in neuropathic pain. Pain, 2003, 102(1-2) : 1-8.
  4. Werhagen L, Budh CN, Hultling C, Molander C. Neuropathic pain after traumatic spinal cord injury relations to gender, spinal level, completeness, and age at the time of injury. Spinal Cord, 2004, 42 : 665-673.
  5. Kanavos P. The rising burden of cancer in the developing world. Annals of Oncology, 2006, 17: 15-23.
  6. Paice JA. Chronic treatment –related pain in cancer survivors. Pain, 2011, 152 : S84-89.
  7. Deng L, Guindon J, Vemuri KV, Thakur GA, White FA, Makriyannis ,Hohmann AG. The maintenance of cisplatin- and paclitaxelinduced mechanical and cold allodyniais suppressed by cannabinoid CB2 receptor activation and independent of CXCR4 signaling in models of chemotherapy-induced peripheral neuropathy, Mol Pain, 2012, 8 : 71
  8. Driessen CM, Kleine-Bolt KM, Vingerhoets AJ, Mols F, Vreugdenhil G. Assesssing the impact of chemotherapy-induced peripheral neuro-toxicity on the quality of life of cancer patients. Support Care Cancer, 2012, 20(4) : 877-81.
  9. Charity D. Scripture, William D. Figg and Alex Sparreboom. Peripheral Neuropathy Induced by Paclitaxel: Recent Insights and Future Perspectives. Current Neuropharmacology, 2006, 4 : 165-172.
  10. Rowinsky EK, Eisenhauer EA, Chaudhry V,Arbuck SG, Donehower RC.Clinical toxicities encountered with paclitaxel (Taxol), Semin Oncol, 1993, 20(4 Suppl 3) : 1–15.
  11. Hilkens, P.H. & ven den Bent, M.J. Chemotherapy-induced peripheral neuropathy. Journal of the peripheral nervous system, 1997, 2(4) : 350-361.
  12. Cata JP, Weng HR, Lee BN, Reuben JM, Dougherty PM: Clinical and experimental findings in humans and animals with chemotherapy-induced peripheral neuropathy. Minerva Anestesiol, 2006, 72 : 151–169.
  13. Arunachalam M and Nirmal S. Attenuating effect of Acorus calamus extract in chronic constriction injury induced neuropathic pain in rats: an evidence of anti-oxidative, anti-inflammatory, neuroprotective and calcium inhibitory effects. BMC Complementary and Alternative Medicine, 2011, 11(1) : 24
  14. Debjit B, Sampath Kumar K.P, Shweta S, Shravan P, Amit S, Dutta D. Traditional Indian Herbs Punarnava and Its Medicinal Importance. Journal of Pharmacognosy and Phytochemistry, 2012, 1(1) : 52-57.
  15. Ujowundu CO, Igwe CU, Enemor VHA, Nwaogu LA, Okafor OE. Nutritive and Anti-Nutritive Properties of Boerhavia diffusa and Commelina nudiflora Leaves, Pakistan Journal of Nutrition, 2008, 7(1) : 90-92.
  16. Sukhdev S, Suman Preet SK, Gennaro L, Dev Dutt R. Extraction technologies for medicinal and aromatic plants, International Centre for science and high technology, 2008.
  17. Raghavan PV. Expert consultant CPSCEA, OECD guideline line. 2000.p. 420
  18. sandeep kumar K, jameela Tahashildar, Karunakar Kota. Neuroprotective effect of ethanolic root extract of Boerhaavia diffusa (Linn.) against Streptozotocin induced Diabetic neuropathy in animal model. Journal of Chemical and Pharmaceutical Research, 2016, 8(3):831-840.
  19. Mangaiarkkarasi A, Rameshkannan S, Meher ali R. Effect of gabapentin and pregabalin  in rat model of taxol induced neuropathic pain. Journal of clinical and diagnostic research, 2015, 9(5) : 11-14.
  20. Xiao W.H, Zheng H, Zheng F.Y, Nuydens R, Meert T.F, Bennett G.J. Mitochondrial abnormality in sensory, but not motor, axons in paclitaxel-evoked painful peripheral neuropathy in the rat, Neuroscience, 2011, 29 : 461–469.
  21. Postma T.J, Benard B.A, Huijgens P.C, Ossenkoppele G.J,  Heimans J.J. Long-term effects of vincristine on the peripheral nervous system, Neurooncology, 1993, 15 : 23–27.
  22. Flatters SJ, Bennet GJ. Studies of peripheral sensory nerves in Paclitaxel induced painful peripheral neuropathy: Evidence for mitochondrial dysfunction, Pain, 2006, 122 : 245–57.
  23. Joseph EK, Levine JD. Caspase siganiling in neuropathic and inflammatory pain in the rat, European Journalof Neuroscience, 2004, 20 : 2896-2902.
  24. Mandeep Kaur, Goel RK. Anti-Convulsant Activity of Boerhaavia diffusa: Plausible Role of Calcium Channel Antagonism. Evidence-Based Complementary and Alternative Medicine, 2011, 4 : 1-7.
  25. Lami NS, Kadota S, Tezuka Y, Kikuchi T. “Constituents of the roots of Boerhaavia diffusa L. II. Structure and stereochemistry of a new rotenoid, boeravinone C2,” Chemical and Pharmaceutical Bulletin, 1990, 38(6) : 1558–1562.
  26. Ray MA, Trammell RA, Verhulst S, Ran S, Toth LA. Development of mouse model for assessing fatigue during chemotherapy, Comparitive Medicine, 2011, 61(2) : 119-130.
  27. Cheatle MD, Foster S, Pinkett A, Lesneski M, Qu D, Dhingra L. Assessing and managing sleep disturbance in patients with chronic pain, Anesthesiol Clin, 2016, 34(2) : 379–93.
  28. Lira F.S. et al., Sleep pattern and locomotor activity are impaired by doxorubicin in non tumor-bearing rats, Sleep Science, 2016, 9 : 232-235.
  29. Meera sumanth and Mustafa S.S. Antistress, Adoptogenic and Immunopotentiating Activity Roots of Boerhaavia diffusa in Mice. International Journal of Pharmacology, 2007, 3(5) : 416-420.
  30. Fidanboylu M, Griffiths LA, Flatters SJ. Global inhibition of reactive oxygen species (ROS) inhibits paclitaxel-induced painful peripheral neuropathy, PLoS One, 2011, 6(9) : e 25212.
  31. Feillet-Coudray C, Rock E, Coudray C, Grzelkowska K, Azais-Braesco V, Dardevet D, et al. Lipid peroxidation and antioxidant status in experimental diabetes, Clin Chim Acta, 1999, 284 : 31-43.
  32. Hadzic T, Aykin-Bur ns N, Zhu Y, Coleman MC, Leick K, Jacobson GM, et al. Paclitaxel combined with inhibitors of glucose and hydroperoxide metabolism enhances breast cancer cell killing via H2O2-mediated oxidative stress, Free Radic Biol Med, 2010, 48(8) : 1024-33.
  33. Gopal TK, Harish G, Chamundeeswari D, Umamaheswara RC. In-vitro AntiOxidant Activity of Roots of Boerhaavia diffusa Linn. Research Journal of Pharmaceutical, Biological and Chemical Sciences. RJPBCS, 2010, 1(4) : 7828.
  34. Aviello G, Canadanovic-Brunet JM, Milic N, Capasso R, Fattorusso E, Scafati TO, et al. Potent antioxidant and genoprotective effects of boeravinone G, a rotenoid isolated from Boerhaavia diffusa, PLos ONE, 2011, 6(5) : 19628.

Corresponding Author

Dr Sandeep Kamlekar

Assistant Professor; Department of Pharmacology, Geetanjali Medical College & Hospital, Udaipur, Rajasthan, India