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Category: Volume 07 Issue 08 August 2019
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Title: Impaired Glucose Regulation in Cirrhosis Liver – The Utility of Oral Glucose Tolerance Test

Authors: Dr Kiruthika Kesavan MD, Dr P. Sureshkumar MD

 DOI: https://dx.doi.org/10.18535/jmscr/v7i8.90

Abstract

Background and Objectives: Liver is one of the major organs to be involved in carbohydrate metabolism, and hence it is no surprise that chronic liver disease is associated with derangements in glucose metabolism. The objectives of this study is to find out the prevalence and clinical implications of the spectrum of glucose metabolism disorders (IGT/DM) in CLD and assess and compare the prognosis of the disease using the Child-Turcotte-Pugh scoring.

Methods: This study was conducted over a period of six months and included 50 patients. Detailed clinical examination along with biochemical and radiological investigations were carried out. OGTT was then performed in these individuals. Patients who were known diabetics, drugs causing hyperglycemia and pregnant women were excluded from the study.

Results: CLD was much more common in males. There was a significant percentage of IGT/DM diagnosed in these patients using OGTT. The results were, 36%-IGT and 28% DM. It was also proved that as the severity of disease worsened, which was assessed by CTP scoring, the degree of hyperglycemia also increase proportionately. The percentage of impaired glucose regulation in Child class A was 47% , class B 68% and class C 93%

Keywords: Chronic liver disease,oral glucose tolerance test, impaired glucose tolerance, diabetes mellitus.

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Corresponding Author

Dr P. Sureshkumar MD.

Assistant Professor, Dept. of General Medicine, Govt. Sivagangai Medical College