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Category: Volume 07 Issue 08 August 2019
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Title: Serum cytokines are related to oxidative stress in Nigerian patients with Parkinson’s disease

Authors: Kazeem Adebayo Oderinu, Olabamiji Abiodun Ajose, Lateef Salawu, Morenikeji Adeyoyin Komolafe, Falilat Adeola Oseni, Olufemi Samuel Smith, Medina Bukola Bello

 DOI: https://dx.doi.org/10.18535/jmscr/v7i8.86

Abstract

Introduction: Parkinson’s disease is a cause of physical disability and impaired quality of life, and oxidative stress is central in the mechanisms of neural degeneration and cell death in the disease. The aim is to investigate the serum levels and relationship of some cytokines and biomarkers of oxidative stress in patients with Parkinson’s disease.

Material and Methods: Forty patients with clinical diagnosis of Parkinson’s disease and forty age- and sex-matched apparently healthy controls were recruited for the study. Their venous blood were collected for the estimation of serum Tumour Necrosis Factor-alpha (TNF-α) and Interferon-gamma (IFN-γ) by enzyme linked immunosorbent assay method. Serum total antioxidant capacity (TAC) and total oxidative status (TOS) were photo metrically determined.

Results: The study showed that mean serum levels of TNF-α and TOS were significantly higher in patients, while serum TAC levels were significantly lower in the patients. There was a positive correlation between serum TNF-α and IFN-γ and both were found to be directly related to serum TOS but not with serum TAC.

Conclusion: The findings from this study suggested that TNF-α increases directly with the TOS levels in patients with Parkinson’s disease.

Keywords: Cytokines; Oxidative stress; Parkinson’s disease.

References

  1. Farombi TH, Owolabi MO, Oguniyi A. Falls and their associated risks in Parkinson's disease patients in Nigeria. J Mov Disord. 2016;9(3):160-5.
  2. Amor S, Puentes F, Baker D, van der Valk P. Inflammation in neurodegenerative diseases. Immunology. 2010;129(2):154-69.
  3. Fischer R, Maier O. Interrelation of oxidative stress and inflammation in neurodegenerative disease: role of TNF. Oxid Med Cell Longev. 2015;2015: 610813 .doi: 10. 1155/2015/610813.
  4. Emerit J, Edeas M, Bricaire F. Neurodegenerative diseases and oxidative stress. Biomed and Pharmacother. 2004;58(1):39-46.
  5. Montgomery SL, Bowers WJ. Tumor necrosis factor-alpha and the roles it plays in homeostatic and degenerative processes within the central nervous system. J Neuroimmune Pharmacol. 2012;7(1):42-59.
  6. Sadek HL, Almohari SF, Renno WM. The inflammatory cytokines in the pathogenesis of Parkinson’s disease. J Alzheimers Dis Parkinsonism. 2014;4:148. doi:10.4172/2161-0460.1000148
  7. Jung JS, Kim DH, Kim HS. Ginsenoside Rh1 suppresses inducible nitric oxide synthase gene expression in IFN-gamma-stimulated microglia via modulation of JAK/STAT and ERK signaling pathways. Biochem Biophys Res Commun. 2010;397(2):323-8.
  8. Lin F, Young HA. The talented interferon-gamma. Advances in Bioscience and Biotechnology. 2013;4: 6 - 13. doi:10.4236/abb.2013.47A3002
  9. Moore DJ, West AB, Dawson VL, Dawson TM. Molecular pathophysiology of Parkinson’s disease. Annu Rev Neurosci. 2005;28:57 - 87.
  10. Brodacki B, Staszewski J, Toczylowska B, Kozlowska E, Drela N, Chalimoniuk M, Stepien A. Serum interleukin (IL-2, IL-10, IL-6, IL-4), TNFalpha, and INFgamma concentrations are elevated in patients with atypical and idiopathic parkinsonism Neurosci Lett. 2008;441(2):158-62.
  11. Eidson LN, Kannarkat GT, Barnum CJ, Chang J, Chung J, Caspell-Garcia C, Taylor P, Mollenhauer B, Schlossmacher MG, Ereshefsky L, Yen M, Kopil C, Frasier M, Marek K, Hertzberg VS, Tansey MG. Candidate inflammatory biomarkers display unique relationships with alpha-synuclein and correlate with measures of disease severity in subjects with Parkinson’s disease. J Neuroinflammation. 2017;14(1):164. doi: 10.1186/s12974-017-0935-1.
  12. Gupta V, Garg RK, Khattri S. Levels of IL-8 and TNF-alpha decrease in Parkinson’s disease. Neurol Res. 2016;38(2):98-102.
  13. Lindqvist D, Kaufman E, Brundin L, Hall S, Surova Y, Hansson O. Non-motor symptoms in patients with Parkinson’s disease––correlations with inflammatory cytokines in serum. PLoS One. 2012;7(10):e47387. doi:10.1371/journal.pone.0047387.
  14. Qin L, Wu X, Block ML, Liu Y, Breese GR, Hong JS, Knapp DJ, Crews FT. Systemic LPS causes chronic neuroinflam-mation and progressive neurodegeneration. Glia. 2007;55(5):453-62.
  15. Gruden MA, Yanamandra K, Kucheryanu VG, Bocharova OR, Sherstnev VV, Morozova-Roche LA, Sewell RD . Correlation between protective immunity to alpha-synuclein aggregates, oxidative stress and inflammation. Neuroimmun-omodulation. 2012;19(6):334-42.
  16. McGeer PL, McGeer EG. Inflammation and neurodegeneration in Parkinson’s Disease. Parkisonism Relat Disord. 2004;10(1):S3-7.
  17. Holmes C, Cunningham C, Zotova E, Woolford J, Dean C, Kerr S, Culliford D, Perry VH. Systemic inflammation and disease progression in Alzheimer disease. Neurology. 2009;73(10):768-74.
  18. Welser-Alves JV, Milner R. Microglia are the major source of TNF-alpha and TGF-beta1 in postnatal glial cultures, regulation by cytokines, lipopolysaccharide, and vitronectin. Neurochem Int. 2013;63(1): 47-53.
  19. Chen H, O'Reilly EJ, Schwarzschild MA, Ascherio A. Peripheral inflammatory biomarkers and risk of Parkinson’s disease. Am J Epidemiol. 2008;167(1):90-5.
  20. Forte G, Alimonti A, Pino A, Stanzione P, Brescianini S, Brusa L, Sancesario G, Violante N, Bocca B. Metals and oxidative stress in patients with Parkinson’s disease. Ann 1st Super Sanita. 2005;41(2):189 - 95.

Corresponding Author

Kazeem Adebayo Oderinu

Department of Chemical Pathology, Obafemi Awolowo University Teaching Hospital Complex, Ile – Ife, Nigeria