Title: To study association of serum magnesium levels with lipid profile in newly diagnosed cases of Type II Diabetes Mellitus in Sub-Himalayan region
Authors: Nishant Nadda, Vinay Bhardwaj, Nidhi Chauhan
DOI: https://dx.doi.org/10.18535/jmscr/v7i8.69
Abstract
Background: Diabetes mellitus is a common endocrinal disorder that is associated with the electrolyte imbalance in the body. Among them the magnesium levels have been found to be corelated with the HbA1C levels. Moreover, magnesium deficiency is associated with lipid metabolism in diabetic patients. Not much studies have been done on correlation between hypomagnesemia and lipid profile in sub-Himalayan region.
Objectives: To study association of serum magnesium levels with lipid profile in newly diagnosed cases of Type II Diabetes Mellitus
Methods: An analytical cross-sectional study was conducted among those newly diagnosed cases of type II diabetes mellitus, who gave consent for the study. The necessary blood investigations were performed and appropriate statistical tests were applied for analysis.
Results: The mean age of the patients was 51.32±10.4 years. A significant positive correlation of serum magnesium was found with serum cholesterol (r= 0.35, p=0.01) and serum high-density lipoproteins (r=0.35, p=0.02). No correlation was found between serum magnesium levels and the age of the newly diagnosed patients of type II diabetes mellitus.
Conclusion: The significant findings of the study concluded the positive correlation of serum magnesium levels with high density lipoproteins and total cholesterol, but this correlation is weak. More elaborate prospective studies are needed to further study on this aspect.
Keywords-Type II Diabetes Mellitus, HbA1C, Serum Magnesium, Lipid profile
References
- Ramachandran, A.; Das, AK. Diabetology. In: Shah Siddharth N, Paul AM, editors. API textbook of medicine. 7th Mumbai: The Association of Physicians of India; 2003. Pp. 1097-1098.
- American Diabetes Association. Standards of medical care in diabetes. Diabetes Care 2007 Jan;30(Suppl 1):S4-S41.
- Car J, Patel H, Srishanmuganathan J, Majeed A. Diabetes care in developing countries. Can Med Assoc J 2004 Jan;176(2): 209-212.
- Goldfine AB, Beckman J A. Life and death in Denmark: lesson about diabetes and coronary heart disease. Circulation 2008 Apr;117: 1914-1917.
- Kuussisto J, Mykkanen L, Pyorala K, Laakso M. NIDDM and its metabolic control predict coronary heart disease in elderly subjects. Diabetes 1944 Aug;43(8): 960-967.
- Institute of Medicine. Food and Nutrition Board. Dietary reference intakes: Calcium, phosphorus, magnesium, vitamin D and fluoride. National Academy Press. Washington DC, 1999.
- Kobrin SM and Goldfarb S. Magnesium deficiency. Semin Nephrol 1990; 10: 525-35
- The significant findings of the study concluded the positive correlation of serum magnesium levels with high density lipoproteins and total cholesterol, but this correlation is weak.
- Yokota K, Kato M, Lister F, et al. Clinical efficacy of magnesium supplementation in patients with type 2 diabetes. J am Coll Nutr. 2004 Oct; 23(5): 506S-9S.
- Rasmussen HS, Aurup P, Goldstein K, et al. Inflence of magnesium substitution therapy on blood lipid composition in patients with ischemic heart disease A double-blind, placebo-controlled study. Arch Intern Med. 1989 May; 149 (5); 1050-1053
- HaggE, Carlberg BC, Hillron VS, Villumsen J. Magnesium therapy in type 1 diabetes. A double bling study concerning effects on kidney function and serum lipid levels. Magnes Res 1999; 12: 123-130.
- Hamid Nasri. Lipid in Association with serum magnesium in diabetes mellitus patients. Bratisl Lek Listy 2008; 109 (7); 302-306
- Schimatschek HF, Rempis R. Prevalence of hypomagnesemia in an unselected German population of 16,000 individuals. Magnes Res 2001;14:283‑
- Sendhav SS, Kakaiya A, Chatterjee B. Evalution of serum magnesium level along with lipid profile in a Gujarati population diagnosed with diabetes mellitus. Indian J Med Biochem 2017;21(2): 112-16