Title: Comparative Study of Effects of Epidural Tramadol and Epidural Buprenorphine on Post Operative An-Algesia in Young Adults

Authors: Dr Ranbhushan Singh, Dr Indra Bhatyal, Dr Konika Razdan, Dr Satya Dev Gupta

 DOI: https://dx.doi.org/10.18535/jmscr/v7i8.62

Abstract

The alleviation of pain, both acute and chronic is an important concern in medical profession. The worldwide search for an appropriate drug to relieve post operative pain is still continuing. Present study was undertaken in search of a better analgesic for post operative analgesia. The study compared 50 mg tramadol given epidurally with 0.15 mg epidural buprenorphine. No other analgesics or sedatives were used. All cases were conducted under regional anaesthesia and the drug was administered through epidural catheter in L 2-3 epidural space. Peak effect of tramadol was for 4 hours whereas with buprenorphine it was 8 hours. The study concluded that he analgesic potency of tramadol is good but much less than that of buprenorphine.

Keywords: Epidural tramadol; Epidural buprenorphine, Post operative analgesia.

References

  1. Gupta A,  Kaur K,  Sharma S, Goyal S, Arora S, and  Murthy RSR. Clinical aspects of acute post-operative pain management & its assessment. J Adv Pharm Technol Res. 2010 Apr-Jun; 1(2): 97–108.
  2. Vadivelu N, Mitra S, and Narayan D. Recent Advances in Postoperative Pain Management. Yale J Biol Med. 2010 Mar; 83(1): 11–25
  3. Pharmacological Management of Cancer Pain in Adults National Clinical Guideline No. 9. www.health.gov.ie/patient-safety/ncec
  4. Brennan F, Carr D and Cousins M. Access to Pain Management—Still Very Much a Human Right. Pain Medicine 2016; 17: 1785–1789
  5. Lohman D, Schleifer R, Amon JJ. Access to pain treatment as a human right. BMC Medicine 2010, 8:8
  6. Pathan H and Williams J. Basic opioid pharmacology: an update. British Journal of Pain 6(1) 11–16
  7. Gholami M,  Saboory E,  Mehraban S,  Niakani A, Banihabib N, Azad MR and Fereidoni J. Time Dependent Antinociceptive Effects of Morphine and Tramadol in the Hot Plate Test: Using Different Methods of Drug Administration in Female Rats. Iran J Pharm Res. 2015 Winter; 14(1): 303–311
  8. Dobkin AB. 1977. Buprenorphine hydrochloride: determination of analgesic potency. Can Anaesth Soc J 24:186–193
  9. Baraka A, Jabbour S, Ghabash M, Nader A, Khoury G. A comparison of epidural tramadol and epidural morphine for post operative analgesia. Can J Anaesthesia 1993, April 40(4): 308-13.
  10. Gadani HN, Patel NB and Gupta SC. Role of butorphanol in preemptive analgesia: A comparison with pentazocine. Anaesth, Pain & Intensive Care 2017;21(1):44-51
  11. Koshy RC, Kuriakose R, Sebastian P et al. Continuous morphine infusions for cancer pain in resource-scarce environments: comparison of the subcutaneous and intravenous routes of administration. J Pain Pall Care Pharmacother 2005;19:27-33.

Corresponding Author

Dr Satya Dev Gupta

Associate Professor, Department of Anaesthesia, Govt. Medical College, Jammu, India