Title: Study of Clinical profile and Antibiotic susceptibility of Urinary Tract Infection in a Tertiary Care Hospital

Authors: Dr J. Louis Ferdin Zeno, Dr M. K. Uthaya Sankar, Dr R. Gopal, Dr I. S. Suman Babu

 DOI: https://dx.doi.org/10.18535/jmscr/v7i8.59

Abstract

Introduction: Urinary tract infection (UTI) is one of the most common infectious disease for which Treatment is often started empirically. The etiology and the antimicrobial susceptibility for UTI have been changing over the years.

Objective: To know about the clinical and microbiological profile of urinary tract infection among patients admitted in Sri Manakula Vinayagar Medical College and Hospital.

Methodology: We conducted a cross sectional study among patients who were diagnosed as UTI based on urine culture. The commonest organism and their antibiotic susceptibility was studied. Ultrasonography (USG) abdomen and pelvis was done to find out any structural abnormalities and complications.

Results: Out of the 40 patients studied, fever(85%) was the most common presenting symptom and Escherichia coli(57.50%) was the most common organism isolated followed by Klebsiella (15%). The most sensitive antibiotic was meropenem (75%) and the most resistant antibiotic was cefazolin(87.50%). These results were found to be statistically significant.

Conclusion: A higher percentage of resistant organisms against the commonly used antibiotics alarm about the indiscriminate use of antibiotics. Hence empirical antibiotic selection should be based on the knowledge of local prevalence of bacterial organisms and their antibiotic sensitivity to avoid the development of resistance.

Keywords: Urinary tract infection (UTI), organisms, antibiotic sensitivity and resistance.

References

  1. Eshwarappa M, Dosegowda R, Aprameya IV, Khan MW, Kumar PS, Kempegowda P. Clinico-microbiological profile of urinary tract infection in south India. Indian journal of nephrology 2011 Jan;21(1):30.
  2. Shah LJ, Vaghela GM, Mahida H. Urinary tract infection: Bacteriological profile and its antibiotic susceptibility in western India. Nat J Med Res 2015;5(1):71-4.
  3. Dalal P, Pethani J, Sida H, Shah H. Microbiological profile of urinary tract infection in a tertiary care hospital. Journal of Research in Medical and Dental Science 2016 Jul;4(3):204-9.
  4. Kakde P, Redkar NN, Yelale A. Urinary tract infection in elderly clinical profile and outcome. JAPI 2018 Jun;66:14.
  5. Vaishnav B, Bamanikar A, Maske P, Rathore VS, Khemka V, Sharma D. Study of clinico-pathological and bacteriological profile of urinary tract infections in geriatric patients with type 2 diabetes mellitus. International Journal of Current Research and Review 2015 Nov 1;7(21):13.
  6. Jaipuriar R, Thyagaraj V. Clinical profile and complications of UTI in diabetic patients. IOSR 2015;14:64-9.
  7. Kasper DL, Hauser SL, Jameson JL, Fauci AS, Longo DL, Loscalzo J. Harrison’s principle of internal medicine. 19th ed. New York: The McGraw-Hill Companies; 2015. p. 2399-40,2426.
  8. Bency J, Priyanka R, Jose P. A study on the bacteriological profile of urinary tract infection in adults and              their antibiotic sensitivity pattern in a tertiary care hospital in central kerala. Int J Res Med Sci 2017                Feb;5(2):66-69.
  9. Aziz N et al. Evaluation of antibiotics sensitivities against UTI pathogens. Int J Curr Microbiol App Sci2016;5(11):46-51.

Corresponding Author

Dr M.K. Uthaya Sankar

Professor, Sri Manakula Vinayagar Medical College and Hospital, Puducherry-605107, India