Title: Correlation between Central Corneal thickness and Intraocular Pressure measured with Goldmann Applanation Tonometer (GAT) in healthy individuals

Author: Dr Shazia Qayum

 DOI: https://dx.doi.org/10.18535/jmscr/v7i5.153

Abstract

Introduction: Intraocular pressure (IOP) measurement is one of the vital and most commonly performed examination in ophthalmology. Goldmann applanation tonometer (GAT) has been labelled as gold standard for measurement of Intraocular pressure. IOP measurement is known to be affected by Central corneal thickness (CCT). It has been stated that thinner corneas leads to false low IOP interpretations while thicker corneas leads to false high IOP interpretations, thus causing apparent normal tension glaucoma (NTG) and ocular hypertension (OHT) respectively.

Objective: To  evaluate the effect of CCT on IOP readings by Goldmann Applanation Tonometry in healthy individuals

Methodology: This prospective study included 200 eyes of 100 patients attending the outpatient department of ophthalmology, from January 2018 to June 2018, in MMIMSR, Mullana. The patients included were devoid of any corneal disorder, history of antiglaucoma medications, keratitis, keratoconus, corneal scar, corneal dystrophy and degeneration. A total number of 200 eyes were investigated using the Ultrasonic topography system and Goldmann Applanation Tonometry. The minimum CCT was 415μm, maximum CCT was 648 μm with mean CCT being 528.5 μm with SD ± 29.48μm. The minimum IOP  recorded was 9 mmHg, maximum IOP was 22 mmHg and mean IOP was 14.92 mmHg with SD ±2.98 mmHg

Conclusion: In our study, we found that Central corneal thickness was correlated with intraocular pressure significantly in both men and women. Athick cornea leads to an overestimation of IOP while thin cornea leads to an underestimation of IOP.

Keywords: Central corneal thickness, Intraocular pressure, Goldmann Applanation Tonometer, pachymetry, Glaucoma.

References

  1. Ehlers N, Bramsen T, Sperling S. Applanation tonometry and central corneal thickness. Acta Ophthalmol. 1975; 53: 34-43.
  2. Whiotacre MM, Stein RA, Hassanein K. The effect of corneal thickness on applanation tonometry. Am J Ophthalmol. 1993;115: 592-6.
  3. Gordon MO, Beiser JA, Brandt JD, et al. The ocular hypertension treatment study: baseline factors that predict the onset of primary open-angle glaucoma. Arch Ophthalmol. 2002; 120: 714-20
  4. Kruse-Hansen F, Ehlers N. Elevated tonometry readings caused by thick cornea. Acta Ophthalmol. 1971; 49: 775-8.
  5. Ehlers N, Kruse-Hansen. Central corneal thickness in low tension glaucoma. Acta Ophthalmol. 1974; 52: 740-6.
  6. Copt RP, Thomas R, Mermoud A. Corneal thickness in ocular hypertension, primary open-angle glaucoma and normal tension glaucoma. Arch Ophthalmol. 1999; 117: 14-6.
  7. Binder PS, Bosem M, Weinreb RN. Scheimpflug anterior segment photography assessment of wound healing after myopic excimer laser photorefractive keratectomy. J Cataract Refract Surg. 1996; 22: 205-12.
  8. Lattimore MR, Kaupp S, Schallhorn S, et al. Orbscan pachymetry: implications of a repeated measures and diurnal variation analysis. Ophthalmology 1999; 106: 977–81
  9. Foster PJ, Baasanhu J, Alsbirk PH, et al. Central corneal thickness and intraocular pressure in a mongolian population. Ophthalmology. 1998; 105: 969–73.
  10. Wolfs RCW, Klaver CCW, Vingerling JR, et al. Distribution of central corneal thickness and its association with intraocular pressure: The Rotterdam Study. Am J Ophthalmol. 1997; 123:767–72.
  11. Lam AKC, Douthwaite WA. The effect of an artificially elevated intraocular pressure on corneal thickness in Chinese eye. OphthalmolPhysiol Opt. 1997; 17: 414–9.
  12. Herndon LW, Choudhri SA, Cox T, et al. Central corneal thickness in normal, glaucomatous, and ocular hypertensive eyes. Arch Ophthalmol. 1997; 115: 1137–41.
  13. Whiotacre MM, Stein RA. Sources of error with use of Goldmann-type tonometers. SurvOphthalmol. 1993; 38: 1-30.
  14. Shah S. Accurate intraocular pressure measurement: The myth of modern ophthalmology? Ophthalmology. 2000; 107: 1805-7
  15. Shields M. Textbook of Glaucoma, 3rd ed. Baltimore: Williams and Wilkins, 1992.
  16. Doughty MJ, Zamam ML. Human corneal thickness and its impact on intraocular pressure measures: A review and metaanalysis approach. SurvOphthalmol. 2000; 44: 367-408.
  17. Johnson M, KassMA,Moses RA, Grodzki WJ. Increased corneal thickness simulating elevated intraocular pressure. Arch Ophthalmol 1978; 96:664–665
  18. Bjornsson G. The primary glaucoma in Iceland: epidemiological studies. Acta Ophthalmol Supplement. 91: 68- 9.
  19. Klein BE, Klein R, Sponsel WE, et al. Prevalence of glaucoma. The Beaver Dam Eye Study. Ophthalmol. 1992; 99: 1499–1504.
  20. Hollows FC, Graham PA. Intra-ocular pressure, glaucoma and glaucoma suspects in a defined population. Br J Ophthalmol.1996; 50: 570–86.

Corresponding Author

Dr Shazia Qayum

MS Ophthalmology DNB Ophthalmology

Assistant Professor, GMC Rajouri (Incharge Head)