Title: Effect of Maternal Hypothyroidism on Thyroid hormone status of fetus: A Hospital based study
Authors: Sanchayan Sinha, Arpita Mandal, Soma Gupta, Chandana Das
DOI: https://dx.doi.org/10.18535/jmscr/v7i5.94
Abstract
Introduction: Thyroid dysfunction is a common endocrinological disorder in pregnancy. It is important for normal development of placenta & early stages of neurodevelopment of foetus. Any deviation from normal activity of thyroid gland is known to be associated with adverse foetomaternal outcome.
Aims & Objectives: The study aims to find out thyroid hormonal status in pregnancy and thereafter to determine prevalence of hypothyroidism. Moreover, it aims to find out the effect of maternal hypothyroidism on fetal thyroid hormonal status.
Materials & Methods: The study included the estimation of TSH and fT4 level of 142 women during delivery. On the basis of thyroid hormonal status, the patients were divided into 2 groups, with hypothyroidism (n=41) & without hypothyroidism (n=101). Thyroid status of baby (TSH & fT4 level of cord blood) was measured. The data was tabulated & analysed using standard statistical method.
Results: Prevalence of hypothyroidism was 28.87%. Statistically significant positive correlation was found between thyroid status of mother & baby [p value >0.001].
Conclusion: maternal hypothyroidism adversely affects the thyroid hormonal status of the fetus; hence early detection of maternal hypothyroidism is very crucial.
Keywords: Thyroid autoimmunity, pregnancy, congenital hypothyroidism.
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