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Category: Volume 07 Issue 05 May 2019
Hits: 2010

Title: Does Secretor Status of ABO Blood Group in Saliva Influence the Risk of Hypertension and Urinary Tract Infection in Diabetic Patients?

Authors: Shanmugapriya Thiagarajan, Selvaraj Stephen, Sarangapani Kanagamuthu, Stanley Ambrose, Pragasam Viswanathan, Palanivel Chinnakali, Rajesh Nachiappa Ganesh

 DOI: https://dx.doi.org/10.18535/jmscr/v7i5.27

Abstract

Secretor status of blood group antigens in saliva is implicated to be associated with several infectious and immune related diseases. Prospective analytical study carried out in a tertiary hospital in South India to study the association of ABO secretor status with type II diabetes mellitus and its microangiopathic complications. A total of 198 patients with type II diabetes mellitus, diagnosed and treated in the hospital were studied. 200 healthy controls were studied from healthy volunteers working in the hospital. ANOVA, Pearson's Chi Square Test and Cox Univariate and Multivariate analysis are the statistical methods used to analyse the data. 21.2% of diabetics and 33.5% of healthy controls were ABO secretors. Secretors were found to have a statistically significant risk of association with type II diabetes mellitus when adjusted for other potential confounding factors. Secretor status was in addition found to have significant association with hypertension. Non-secretors were significantly associated with increasing age of the patient and had increased risk of urinary tract infections (UTI). The risk of microangiopathic complications due to type II diabetes mellitus were significantly higher with increasing levels of glycated haemoglobin (HbA1c). In our study, we found significant association of secretors with type II diabetes mellitus and hypertension while non-secretors were associated with increased risk of urinary tract infections.

Keywords: Secretor status, Type II diabetes mellitus, Hypertension, UTI, microangiopathic Complications.

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Corresponding Author

Dr Rajesh Nachiappa Ganesh

Additional Professor, Department of Pathology, JIPMER, Puducherry – 605006, India

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