Title: Fine Needle Aspiration Cytology of Mesenchymal Tumours

Authors: Dr Sanjay N. Parate, Dr Harshwardhan Bahirat

 DOI: https://dx.doi.org/10.18535/jmscr/v7i3.187

Abstract

Introduction: FNA of musculosketal masses provides a number of advantages and disadvantages. However FNA of soft tissue and bone is not widely accepted to obtain a definitive diagnosis for tumours. This study aims to establish the diagnostic accuracy of fine needle aspiration cytology in diagnosing mesenchymal tumours with reference to the subsequent histopathology report.

Material and Methods: 634 patients were studied over a period of 2 years. A comparison was made between cytological and histological findings whenever possible. On correlation the sensitivity, specificity, accuracy and positive predictive value were calculated

Result: Out of 634 cases, 54.36% of benign mesenchymal and 62.5% of malignant mesenchymal tumours were seen in males. 45.63% of benign and 37.5 % of malignant mesesnchymal tumours were seen in females. Soft tissue tumours (91.95%) were found to be much more common as compared to bone tumours (8.05%). The Sensitivity, Specificity and diagnostic accuracy of FNA of malignant lesions was found to be 90%, 97.72% and 95.31% respectively.

Conclusion: The present study concluded that FNA is fairly reliable for correct preoperative diagnosis and management of mesenchymal tumours.

Keywords:  Cyto-histo correlation, FNAC, Histopathology, Mesenchymal, Soft tissue tumours

References

  1. Collins P. Section 2 Embryogenesis.In: Gray’s Anatomy: The Anatomical basis of clinical practice. Edited by Strandings S. 19th Churchill Livingstone: pp 165-211.
  2. Sandler T W. Skeletal system and Muscular system.In: Langman’s medical embryology 9th Philadelphia: Lippincott Williams & Wilkins, 2004: pp 171-209.
  3. Berger‐Richardson D, Swallow CJ. Needle tract seeding after percutaneous biopsy of sarcoma: risk/benefit considerations. Cancer. 2017 Feb 15;123(4):560-7.
  4. Geisinger K R, Abdul-Karim F W. Fine Needle Aspiration Biopsy of Soft Tissue Aspiration of Soft Tissue tissue tumours.In: Enzinger and Weiss’s soft tissue tumours, 5th edition, Elsevier publications 2008:103-115.
  5. Khalbuss WE, Teot LA, Monaco SE. Diagnostic accuracy and limitations of fine‐needle aspiration cytology of bone and soft tissue lesions: A review of 1114 cases with cytological‐histological correlation. Cancer cytopathology. 2010 Feb 25;118(1):24-32.
  6. Bezabih M. Cytological diagnosis of soft tissue tumours. Cytopathology. 2001 Jun;12(3):177-83.
  7. Nagira K, Yamamoto T, Akisue T, Marui T, Hitora T, Nakatani T, Kurosaka M, Ohbayashi C. Reliability of fine‐needle aspiration biopsy in the initial diagnosis of soft‐tissue lesions. Diagnostic cytopathology. 2002 Dec;27(6):354-61.
  8. Roy M, Bhattacharyya A, Sanyal S, Roy A, Dasgupta S. Fine needle aspiration cytology of bone and joint lesions: an assessment. Journal of the Indian Medical Association. 1995 Jul;93(7):259-61.
  9. Soni PB, Verma AK, Chandoke RK, Nigam JS. A prospective study of soft tissue tumors histocytopathology correlation. Pathology research international. 2014;2014.
  10. Jorda M, Rey L, Hanly A, Ganjei‐Azar P. Fine‐needle aspiration cytology of bone: Accuracy and pitfalls of cytodiagnosis. Cancer Cytopathology. 2000 Feb 25;90(1):47-54.
  11. Handa U, Bal A, Mohan H, Bhardwaj S. Fine needle aspiration cytology in the diagnosis of bone lesions. Cytopathology. 2005 Apr;16(2):59-64.
  12. Kumar R, Rao C, Hazarika D, Mukherjee G, Gowda B.Aspiration Biopsy cytology of Primary Bone Lesions:Acta Cytol 1993;37(1):83-89.
  13. Kabukçuoğlu F, Kabukçuoğlu Y, Kuzgun U, Evren I. Fine needle aspiration of malignant bone lesions. Acta cytologica. 1998;42(4):875-82.
  14. Hirachand S, Lakhey M, Singha AK, Devkota S, Akhter J. Fine needle aspiration (FNA) of soft tissue tumours (STT). Kathmandu University medical journal (KUMJ). 2007;5(3):374-7.
  15. Kilpatrick SE, Cappellari JO, Bos GD, Gold SH, Ward WG. Is fine-needle aspiration biopsy a practical alternative to open biopsy for the primary diagnosis of sarcoma? Experience with 140 patients. American journal of clinical pathology. 2001 Jan 1;115(1):59-68.

Corresponding Author

Dr Harshwardhan Bahirat

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