Details
Category: Volume 07 Issue 01 January 2019
Hits: 1004

Title: Comparative evaluation of 25-Hydroxy vitamin D levels among women with polycystic ovarian syndrome and normal women of reproductive age group attending a tertiary care hospital

Authors: Dr Rukhsana Sami, Dr Sheikh Mohd Saleem, Dr Qazi Haroon

 DOI: https://dx.doi.org/10.18535/jmscr/v7i1.107

Abstract

 

Background: Polycystic Ovary Syndrome (PCOS) has been termed as the most common endocrine entity encountered by the women of the reproductive age group. The aim of the study was to find the comparison between Vitamin D levels among Normal women and Women with PCOS in the reproductive age group at one of the largest maternity hospitals of Kashmir Valley.

Methods: The study was a cross-sectional study which was carried out at one of the largest maternity tertiary care hospitals of Kashmir Valley. Women in the reproductive age group, women diagnosed with PCOS using clinical or Ultrasound criteria. For comparison, women who attended the outpatient department for any cause other than PCOS were included in the study.

Results: The mean age of the patients was 28 ± 8 years in PCOS women and 27 ± 6 years among normal women without PCOS. Majority 99 (66%) of the patients without PCOS were having serum fasting insulin levels within normal range while 123 (82%) among PCOS were having increased levels of serum fasting insulin levels. Moreover, 148 (99%) of PCOS patients fall under any one of the categories of Vitamin D deficiency while the reverse was true for women without PCOS.

Conclusion: Fasting serum Insulin levels and Serum 25(OH) Vitamin-D levels were significantly lower in PCOS women than the normal women in the reproductive age group.

Keywords: PCOS, Ovarian Disease, 25(OH) D Levels, Insulin Levels.

References

  1. Li H,  Brereton  R,  Anderson  R  et    (2011): Vitamin D  deficiency  is  common  and  associated  with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism,60:1475-1481.
  2. Haoula Z,  Salman  M  and  Atiomo  W  (2012): Evaluating the association between endometrial cancer and  polycystic  ovary    Hum.  Reprod., 27:1327-1331.
  3. Studzinski G, McLane J and Uskokovic M (1993):Signaling pathways  for  vitamin  D-induced differentiation: implications for therapy of proliferative and  neoplastic    Crit.  Rev.  Eukaryot.  Gene Expr.,3:279-312.
  4. Irani M and Merhi Z (2014): Role of vitamin D in ovarian physiology and its implication in reproduction: a systematic review. Fertil. Steril., 102: 460-469.
  5. N. Kalro, T. L. Loucks, and S. L. Berga, Neuromodulation in polycystic ovary syndrome, Infertility and Reproductive Medicine Clinics of North America, 14, no. 4,529–555, (2003).
  6. Speroff and MA. Fritz, Chronic Anovulation and The Polycystic Ovary Syndrome,in Clinical Gynecologic, Endocrinology and Infertility, 495–533, 2011, 8th ed.
  7. Wehr, S. Pilz, N. Schweighofer, A. Giuliani, D. Kopera, T. R. Pieber, and B.Obermayer-Pietsch, Association of hypovitaminosis D with metabolic disturbancesin polycystic ovary syndrome, European Journal of Endocrinology, 161, no. 4, 575–582,(2009).
  8. Wehr, O. Trummer, A. Giuliani, H.-J. Gruber, T. R. Pieber, and B. Obermayer-Pietsch,Vitamin D-associated polymorphisms are related to insulin resistance and vitaminD deficiency in polycystic ovary syndrome, European Journal of Endocrinology, 164,no. 5, 741–749, (2011).
  9. F. Holick, Medical progress: Vitamin D deficiency, New England Journal ofMedicine, 357, no. 3, 266–281, (2007).
  10. Lips P  (2010):  Worldwide  status  of  vitamin  D nutrition. J .Steroid .Biochem Mol. Biol.,121:297-300.
  11. Holick M  (2007):  Medical  progress:  vitamin  D deficiency.  New  England  Journal  of  Medicine,3:  266–281.
  12. Franks S  (1995):  polycystic  ovary  pathogenesis of PCOS. N. Engl. J. Med., 333:853-861.
  13. Sheikh Mohd Saleem. Modified Kappuswamy scale updated for year 2018. Indian J Res. 2018;7(3):6–7.
  14. Ngo D,  Chan  W,  Rajendran  S  et  Determinants  of  insulin  responsiveness  in  young women: Impact of polycystic ovarian syndrome,  nitric oxide and vitamin D. Nitric Oxide,2011. 25: 326–330.
  15. Mahmoudi T,  Gourabi  H,  Ashrafi  M  et  Calciotropic  hormones,  insulin  resistance  and the  polycystic  ovary  syndrome.  Fertility  and  Sterility, 2010.93: 1208–1214.
  16. Moini A,  Shirzad  N,  Ahmadzadeh  M  et  Comparison  of  25-hydroxyvitamin  D  and calcium  levels  between  polycystic  ovarian  syndrome and normal women. Int. J .Fertil. Steril.2015, 9: 1-8.
  17. Figurová J,  Dravecká  I,  Javorský  M  et  Prevalence  of  vitamin  D  deficiency  in  Slovak women with polycystic ovary syndrome and its relation to  metabolic  and  reproductive  abnormalities.  Wien. Klin. Wochenschr.2016,10: 1-8.
  18. Elida S,  Binarwan  H,  Muhammad  F  et  Vitamin  D  levels  in  women  with  polycystic ovary syndrome. ASPIRE Conference Proceedings, The 6thCongress  of  the  Asia  Pacific  Initiative  on Repro-duction. KNE Medicine, 2016.125:88-95
  19. Wehr E,  Pilz  S,  Schweighofer  N  et  Association  of  hypovitaminosis  D  with  metabolic disturbances  in  polycystic  ovary  syndrome  Eur.  J Endocrinol.2009 ,161:575-82.

Corresponding Author

Dr Sheikh Mohd Saleem

Demonstrator, Department of Community Medicine, Government Medical College, Srinagar