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Category: Volume 07 Issue 01 January 2019
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Title: Study of Spectrum of Histopathological Findings in Breast Carcinomas, after Neoadjuvant Chemotherapy

Authors: Dr Renuka Gahine, Dr Shashikala Kosam, Dr Sandhya Verma

 DOI: https://dx.doi.org/10.18535/jmscr/v7i1.104

Abstract

 

Background: Neoadjuvant chemotherapy is currently established as a standard therapeutic approach for patients with large (>2 cm) and locally advanced breast cancer. The histopathological evaluation of tumor response is the gold standard.

Methods: Histopathologic examination was done in 44 MRM specimen received in the department of pathology over a period of 1 year from August 2017 to July 2018.

Results: 44/44 cases are of female breast. Mean age of patient is 50 years. Mean size before CT was 56.14 cm2 and after CT was 29.40 cm2. In the present study 18% cases show complete pathologic response and 84% cases show incomplete response.

Conclusion: Characteristic pattern of changes observed after histopathological examination of tumor bed are cellular fibrous tissue, reactive lymphocytic infiltration, haemosiderin laden macrophages, areas of coagulative necrosis, stromal hyalinization, dystrophic calcification.

Keywords: Neoadjuvant chemotherapy, breast carcinoma, pathologic response.

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Corresponding Author

Dr Sandhya Verma

Address- R-11, Street no. 3, Dubey colony, Mowa Raipur Pin Code:492007, India

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