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Category: Volume 06 Issue 08 August 2018
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Title: In-vivo biological effect of Carica papaya leaf extracts on P-407 induced hyperlipidemic Albino Wistar rats

Authors: Sheneni Victor Duniya, Okpe John Mathias, Abaniwo Rose Mafo, Idakwoji Precious Adejoh, Adamu Danjuma Adamu, Mamudu Collins Ojonugwa

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i8.202

Abstract

To determine the biological effect of Carica papaya leaves extracts Poloxamer induced hyperlipidemia. Thirty-five healthy albino rats of the same sexes weighing 150-200g were divided into seven; group given feed and water only, group induced by an intra-peritoneal injection of P-407, groups induced and treated with methanol, ethanol, ethyl acetate, n-butanol and n-hexane leaves extracts. In all the groups, P-407 and the extracts were administered at a dose of 1000mg/kg and 30mg/kg body weight respectively. At the end of the 14 day, the animals were sacrificed and blood sample were collected for determination of serum levels of: Total cholesterol (TC), Triacylglycerides (TG), Low-density lipoprotein (LDL) and High-density lipoprotein (HDL). The studies showed that animals in induced treated groups significantly (P<0.05) lower serum levels of TC, TG, LDL and significantly (P<0.05) increased HDL when compared to the P-407 induced hyperlipidemia control. The studies show the phytotherapeutic effect of Carica papaya leaves extracts (methanol, ethanol, ethyl acetate, n-butanol and n-hexane) in P-407 induced hyperlipidemia.

Keywords: Biological effect, Carica papaya, Poloxamer 407, Hyperlipidemia.

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Corresponding Author

Sheneni, Victor Duniya

Dept of Biochemistry, Faculty of Natural Sciences, Kogi State University, PMB 1008, Anyigba, Nigeria

Tel: +234- 8033519009; Email: This email address is being protected from spambots. You need JavaScript enabled to view it.