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Category: Volume 06 Issue 08 August 2018
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Title: Study of lipid peroxide levels and status of antioxidant enzymes in alcoholic hepatitis patients

Authors: Sanjay Bhatt, M. Itagappa, J. B.Gogoi

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i8.175

Abstract

Background: The real status of pro-oxidant and antioxidant in alcoholic hepatitis is still not clear.

Material & Methods: This study was conducted in Department of Biochemistry, Santosh medical college & Hospital. 40 alcoholic hepatitis patients were subjected to detailed clinical examination and laboratory investigations and the results were compared with 40 controls. Blood samples were collected for oxidative stress parameters. It was observed that there was a significant increase in activities of SOD, MDA and Catalase activity in patients with alcoholic hepatitis when compared to controls.

Results: Result of this study depict higher oxygen free radical production, evidenced by elevated levels of MDA and decreased levels of Catalase activity, supporting the evidence of oxidative stress in alcoholic hepatitis patients. Increased activities of antioxidant enzymes might be a compensatory regulation of body in response to increased oxidative stress.

Conclusion: Data of this study represent that antioxidant defense mechanisms might be impaired in patients with alcoholic hepatitis. These findings also provide a theoretical basis for development of novel therapeutic strategies, such as antioxidant supplementation.

Keywords: Superoxide dismutase (SOD), Catalase, Alcoholic Hepatitis (AH).

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Corresponding Author

Sanjay Bhatt, Ph.D. Scholar

Santosh Medical College & Hospital, Santosh University, Ghaziabad, UP, India