Title: Coronary Angiographic (CAG) Findings between Diabetic and non diabetic Patients in Coronary artery disease: A Comparative Study

Authors: Dr Rajiv Girdhar, Dr Yogesh Kothari, Dr Anuj Sanjay Kamat, Dr Ram Anil Raj, Dr Bryan Jacob Koithara

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i8.126

Abstract

Introduction: Coronary artery disease (CAD) accounts for the major chunk of mortality in diabetes. Coronary angiography or arteriography remains the “gold-standard” technique for diagnosing and evaluating CAD.

Material and Methods: The present study was undertaken at Rajarajeswari Medical College and  Hospital, Bangalore , India  between the periods of 1ST December- 2016 to  31st June -2018.

Percutaneous coronary angiography (CAG) was Performed in 200 consecutive patients with suggestive of ischaemic chest pain. The population consisted of of which 75 cases are diabetic  and 125 cases are non-diabetic

Results: We observed positive angiographic lesion among both groups comparing site & number of vessel(s) involvement also average percentage of stenosis. The presence of coronary risk factors was not significantly different between the two populations. Total positive angiographic lesion was 131 (65.5%) in both groups. Among the Diabetes mellitus patients positive CAG finding 61 (81.33%).The recognized lesions were single vessel disease (SVD) 16 (26.24),double vessel disease (DVD) 25 (40.98%), triple vessel disease (TVD) 20 (32.78%), diffuse lesions 6 (9.8%) and average vessel stenosis 82.63%. On the other hand, total positive angiographic lesion was 70 (56%) in non--diabetic group; among them single vessel disease (SVD) 23 (32.85%), double vessel disease (DVD) 28(40%), triple vessel disease (TVD) 19 (27.15%), no diffuse lesions was found and average vessel stenosis was 78.03%. The results of the angiographic finding suggest that diabetic patients have a higher incidence of coronary heart disease (CHD), DVD, TVD, diffuse lesion & marked stenosis of coronary vessel than nondiabetic patient.

Conclusion: CAD in diabetics had considerably higher percent of severe and unpredictable presentation. This increased frequency of complex lesion morphology is more difficult to treat by definitive intervention like percutaneous transluminal coronary angioplasty (PCI) & coronary artery bypass graft (CABG). Diabetics have a higher risk factor profile and poor clinical outcome. Early diagnosis and appropriate management will reduce the risk of complication after the onset of disease.

Keywords: Coronary artery disease, Coronary angiogram, Diabetes mellitus, Non –diabetics.

References

  1. Fein F, Scheuer J. Heart disease in diabetes. In: Rifkin H Jr, ed. Diabetes Mellitus: Theory and Practice. New York, NY: Elsevier Science Publishing Co Inc; 1990:812-823
  2. Usitupa M, Siitonen O, Aro A. Prevalence of coronary heart disease, left ventricular failure and hypertension in middle-aged, newly diagnosed type 2 (non-insul independent) diabetic subjects. Diabetologia. 1985;28:22- 27
  3. Bryfogle JW, Bradley RF. The vascular complications of diabetes mellitus. Diabetes. 1957;6:159-167
  4. Anderson RS, Ellington A, Gunter LM. The incidence of arteriosclerotic heart disease in negro diabetic patients. Diabetes. 1961;10:114-118
  5. Epstein FH, Ostrander LD Jr, Johnson BC, Payne MW, Hayner NS, Keller JB, Francis T. Epidemiological studies of cardiovascular disease in a total community: Tecumseh, Michigan. Ann Intern Med. 1965;62:1170- 1187
  6. Kannel WB, Dawber TR, Kagan A, Revotskie N, Stokes J. Factors of risk in the development of coronary heart disease: six-year follow-up experience:
  7. Haffner SM, Lehto S, Ronnemaa T, et al. Mortality from coronary heart disease in subject with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. NEng J of med.1998;339:229- 234
  8. Laing SP, Swerdlow AJ, Slater SD, etal. Mortality from heart disease in a cohort of 23000 patients with insulin treated diabetes.Diabetologia.2003;46:760- 765
  9. Geiss LS, Herman WH, Smith PJ. Mortality in noninsulin dependent diabetes. In: Diabetes in America.2nd ed. National Diabetes Data Group, National institutes of Health, National Institute of Diabetes and Digestive and Kidney Disease, NIH publication No.95-1468,1995; 233-257
  10. Hamby R, Sherman L, Mehta J, Aintablian A. Reappraisal of the role of the diabetic state in coronary artery disease. Chest. 1976;70:251-257
  11. Waller B, Palumbo P, Roberts W. Status of the coronary arteries at necropsy in diabetes mellitus with onset after age 30 years. Am J Med. 1980;69:498-506
  12. Fein F. Heart disease in diabetes. Cardiovasc Rev Rep. 1982;3:877-893
  13. Rosove M, Harrison F, Harwig M. Plasma Bthromboglobulin, platelet factor 4, fibrinopeptide A, and other hemostatic functions during improved short-term glycemic control in diabetes mellitus. Diabetes Care. 1984;7:174-179
  14. MacRury S, Lowe G. Blood rheology in diabetes mellitus. Diabet Med. 1990;7:285-291
  15. Breddin H, Krzywanek H, Althoff P, Schoffling K, Ubeila K. PARD: Platelet aggregation as a risk factor in diabetes: Results of a prospective study.HormMetab Res. 1985;15:63-68
  16. https://www.nhlbi.nih.gov/ files/docs/ guidelines/ express.pdf
  17. http://www.ndei.org/ uploaded Files/ Common/ NDEI/ Treatment_Guidelines/ ADA%202015%20Summary%20PDF.pdf
  18. Nathan DM, Meigs J, Singer DE. The Epidemiology of cardiovascular disease in Type 2 diabetes mellitus: How sweat it is/or is it. The Lancet 1997;350(s1):s14-8.
  19. Mak KH, Moliterno DJ, Granger CB, Miller DP, White HD, Wilcox RG, et al. Influence of Diabetes Mellitus on Clinical Outcome in the thrombolytic era of Acute Myocardial Infarction-GUSTO-1 Investigations J. Am. Coll. Cardiol. 1997;30:171-9
  20. Moreno Pedro R, Murcia Alvaro M, Palacios Igor F, Leon Miltiadis N, Bernardi Victor H, FusterValentín, Fallon John T. Coronary Composition and Macrophage Infiltration in Atherectomy Specimens From Patients With Diabetes Mellitus. J of the American Heart Association October 2000; 102 (18): 2180-2184
  21. Jose A. Silva, Alvaro Escobar,Tyrone J. Collins, Stephen R. Ramee, Christopher J. White. Unstable Angina, A Comparison of Angioscopic Findings Between diabetic and nondiabetic Patients. j of American Heart Association. 1995;92:1731-1736
  22. Henry P, Makowski S, Richard P, Beverelli F, Casanova S, Louali A, et al. Increased incidence of moderate stenosis among patients with diabetes: Substrate for myocardial infarction? Am Heart J 1997;134:1037-43.
  23. Sousa JM, Herrman JL, Teodoro M, Diogo S, Terceiro BB, Paola AA, et al. Comparison of coronary angiography findings in diabetic and non-diabetic women with non-ST-segment-elevation acute coronary syndrome. Arq Bras Cardiol 2006;86:150-5.
  24. Mossavi M, Nematipour E, Mehrpooya M. Comparison of extent of coronary artery disease in angiography of diabetics and non-diabetics. Iran Heart J 2006;7:37-42.
  25. Uddin SN, Malik F, Bari MA, Siddiqui NI, Khan GK, Rahman S, et al. Angiographic severity and extent of coronary artery disease in patients with type 2 diabetes mellitus. Mymensingh Med J 2005;14:32-7.
  26. Nicholls SJ, Tuzcu EM, Kalidindi S, Wolski K, Moon KW, Sipahi I, et al. Effect of diabetes on progression of coronary atherosclerosis and arterial remodeling: A pooled analysis of 5 intravascular ultrasound trials. J Am Coll Cardiol 2008;52:255-62.
  27. Rana JS, Dunning A, Achenbach S, Al-Mallah M, Budoff MJ, Cademartiri F, et al. Difference in prevalence, extent, severity and prognosis of coronary artery disease among patients with and without diabetes undergoing coronary computed tomography angiography. Diabetes Care 2012;35:1787-94.
  28. Fox CS, Sullivan L, D’Agostino RB Sr, Wilson PW; Framingham Heart Study. The significant effect of diabetes duration on coronary heart disease mortality: The Framingham Heart Study. Diabetes Care 2004;27:704-8.

Corresponding Author

Dr Rajiv Girdhar

DM Cardiology PG, Rajarajeswari Medical College and Hospital,

Mysore Road, Bangalore 560074, India