Title: A Comparative Study of Lipid Profile and Atherogenic Index of Plasma among Women with Rheumatoid Arthritis and without Rheumatoid Arthritis
Authors: Dr Silpa Thota, Dr Madhavi Kondeti, Dr Palla Nagadasaiah, Dr Pasupurekula Laxmi
DOI: https://dx.doi.org/10.18535/jmscr/v6i8.72
Abstract
The clinical association between Rheumatoid arthritis (RA) and cardiovascular diseases (CVD) is important as the patients with rheumatoid arthritis are more prone to cardiovascular morbidity and mortality. Dyslipidemia appears to be present very early in the RA disease process which contributes to accelerated atherosclerosis among these individuals. Female gender is considered as risk factor for rheumatic diseases. So, this study aims at comparing the lipid profile levels and Atherogenic index of plasma (AIP) among women with RA and women without RA. This observational study was conducted totally on 80 women in the age group of 30 to 60 years. Among them 40 women were clinically diagnosed with RA (as per 1987 ACR criteria) who are taken as group 1 and 40 women were without RA who are taken as group 2. Serum lipid profiles parameters were estimated and Atherogenic index of plasma was calculated. These values were expressed in mean± standard deviation. The values are compared among both the groups and statistical significance was observed. Serum total cholesterol(TC), triglycerides(TAG), low density lipoprotein(LDL), very low density lipoproteins(VLDL) and Atherogenic index of plasma were significantly increased in women with RA and high density lipoprotein(HDL) was significantly decreased in women with RA when compared with women without RA. Women with RA are characterized by atherogenic lipid profile in comparison with women without RA. Early diagnosis and treatment of RA along with screening of hyperlipidemias can reduce cardiovascular related mortality and morbidity in these patients.
Keywords: Atherogenic index of plasma; Cardiovascular risk; Lipid profile; Lipoproteins; Rheumatoid arthritis.
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