Title: Clinical profile of diabetic patients with heart failure admitted in tertiary care teaching hospital, Kishanganj, Bihar- An Observational Study

Authors: Dr Anuj Kumar Saha, Dr Sumit Sharma, Dr Ichchhit Bharat, Dr Raghwendra Singh

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i8.46

Abstract

Background: Diabetes mellitus and heart failure are two multifaceted entities characterised by high morbidity and mortality. Early epidemiological and prospective studies have observed the frequent co-existence of both conditions. 

Methodology: An echocardiography was done and investigations like complete haemogram, HbA1C, FBS, PPBS, renal profile and fasting lipid profile was also done. Echocardiography was done by Siemens CV70 machine in department of cardiology and HbA1C was measured by High Pressure Liquid Chromatographic method in department of biochemistry.

Results: A total of 100 patients coming with signs and symptoms of HF who are also diabetic were selected for the study, in whom 72 were male and 28 were female. Predominant symptoms were shortness of breath (100%) followed by swelling of legs (48%) and palpitation (29%). History suggestive of paroxysmal nocturnal dyspnea was present in 27 (27%) patients. Atrial fibrillation was observed in 23% cases. LVEF [<50%] was recorded 62% cases at presentation. Mean HbA1C was 7.3±0.9. Anaemia was reported about 31% cases. Dyslipidemia was noticed about 47% of the study participants with diabetes with heart failure. Among 100 patients 62 (62%) presented with left ventricular ejection fraction <50% and 38 (38%) presented with left ventricular ejection fraction ≥50%.

Conclusion: Diabetes is an independent risk factor for the development of congestive heart failure and heart failure patients with diabetes have a worse prognosis than those without diabetes.

Keywords: Diabetes mellitus, Heart failure, Clinical Profile, Left ventricular ejection fraction.

References

  1. Guariguata L, Whiting DR, Hambleton I, et al., Global estimates of diabetes prevalence for 2013 and projections for 2035, Diabetes Res Clin Pract, 2014;103:137–49. 
  2. Tousoulis D, Papageorgiou N, Androulakis E, et al., Diabetes mellitus-associated vascular impairment: novel circulating biomarkers and therapeutic approaches, J Am Coll Cardiol, 2013;62:667–76.
  3. Barber SR, Davies MJ, Khunti K, Gray LJ, Risk assessment tools for detecting those with pre-diabetes: A systematic review, Diabetes Res Clin Pract, 2014;105(1):1–13.
  4. McMurray JJ, Adamopoulos S, Anker SD, et al., ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC, Eur Heart J, 2012; 33:1787–847.
  5. Vasiliadis I, Kolovou G, Kolovou V, et al. Gene polymorphisms and thyroid function in patients with heart failure, Endocrine, 2014;45:46–54.
  6. Dimitris Tousoulis, Evangelos Oikonomou, Gerasimos Siasos, Christodoulos Stefanadis. Diabetes Mellitus and Heart Failure. European Cardiology Review 2014;9(1):37–42.
  7. McAlister FA, Teo KK, Taher M, et al. Insights into the contemporary epidemiology and outpatient management of congestive heart failure. Am. Heart J. 1999; 138(1 Pt 1):87–94.
  8. Thomas MC. Type 2 Diabetes and Heart Failure: Challenges and Solutions. Curr Cardiol Rev. 2016 Aug; 12(3): 249–255.
  9. Lind M, Bounias I, Olsson M, et al. Glycaemic control and incidence of heart failure in 20,985 patients with type 1 diabetes: an observational study. Lancet. 2011; 378(9786):140–146.
  10. Erqou S, Lee CT, Suffoletto M, et al. Association between glycated haemoglobin and the risk of congestive heart failure in diabetes mellitus: systematic review and meta-analysis. Eur. J. Heart Fail. 2013; 15(2):185–193.
  11. McKee PA, Castelli WP, McNamara PM, Kannel WB. The natural history of congestive heart failure: the Framingham study. N Engl J Med. 1971;285:1441–6.
  12. Bursi F, Weston SA, Redfield MM, et al. Systolic and diastolic heart failure in the community. JAMA. 2006; 296:2209–16.
  13. American Diabetes Association: Report of the expert committee on the diagnosis and classification of diabetes mellitus. Diabetes Care 1997; 20: 1183–97.
  14. Clark CM, Perry RC. Type 2 diabetes and macro vascular disease. Epidemiology and etiology. Am Heart J 1999; 138: 330–3
  15. Wan S-H, Vogel MW, Chen HH. Preclinical Diastolic Dysfunction. Journal of the American College of Cardiology. 2014;63(5): 407-416.
  16. Kannel WB, McGee DL. Diabetes and cardiovascular disease. The Framingham study. J Am Med Assoc 1979; 214: 2035–8.
  17. Tsujino T, Kawasaki D, Masuyama T. Left ventricular diastolic dysfunction in diabetic patients: pathophysiology and therapeutic implications. Am J Cardiovasc Drugs.2006; 6(4):219-30.
  18. From AM, Scott CG, Chen HH. The Development of Heart Failure in Patients with Diabetes Mellitus and Preclinical Diastolic Dysfunction: A Population Based Study Journal of the American College of Cardiology. 2010;55(4):10.1016/j.jacc.2009.12.003.
  19. Patil MB, Burji NP. Echocardiographic evaluation of diastolic dysfunction in asymptomatic type 2 diabetes mellitus. J Assoc Physicians India.2012 May; 60:23-6.
  20. The CONSENSUS trial study group. Effect of enalapril on mortality in severe congestive heart failure. N Engl J Med 1987; 316: 1429–35.
  21. The SOLVD investigators. Effect of enalapril on survival in patients with reduced left ventricular ejection fraction and congestive heart failure. N Engl J Med 1991; 325: 293–302.
  22. Cohn JN, Johnson G, Ziesche S et al. A comparison of enalapril with hydralazine-isosorbide dinitrate in the treatment of chronic congestive heart failure. N Engl J Med 1991; 325: 303–10.
  23. Packer M, Poole-Wilson PA, Armstrong PW et al. on behalf of the ATLAS Study Group. Comparative effects of low doses and high doses of the angiotensin converting enzyme inhibitor lisinopril on morbidity and mortality in chronic heart failure. Submitted, 1998.
  24. Aguilar D, Bozkurt B, Ramasubbu K, et al. Relationship of hemoglobin A1C and mortality in heart failure patients with diabetes. J. Am. Coll. Cardiol. 2009;54 (5):422–428.
  25. Schindler DM, Kostis JB, Yusuf S et al. for the SOLVD investigators. Diabetes mellitus: a predictor of morbidity and mortality in the studies of left ventricular dysfunction (SOLVD) trials and registry. Am J Cardiol 1996; 77: 1017–20.
  26. Suskin N, McKelvie RS, Roteaus J, Sigouin C, Wiece KE, Yususf S. Increased insulin and glucose levels in heart failure. J Am Coll Cardiol 1998; 3 (Suppl): 249A.
  27. Gwilt DJ, Petri M, Lewis PW, Nattrass M, Pentecost BL. Myocardial infarct size and mortality in diabetic patients. Br Heart J 1985; 54: 466–72.
  28. Singer DE, Moulton AW, Nathan DM. Diabetic myocardial infarction. Interaction of diabetes with other preinfarction risk factors. Diabetes 1989; 38: 350–7.
  29. Melchior T, Gadsboll P, Hildebrandt P, Kober L, Torp-Pedersen C. Clinical characteristics, left and right ventricular ejection fraction, and longterm prognosis in patients with non-insulin-dependent diabetes surviving and acute myocardial infarction. Diabetic Med 1996; 13: 450–6.
  30. Amato L, Paolisso G, Cacciatore F, et al. Congestive heart failure predicts the development of non-insulin-dependent diabetes mellitus in the elderly: the Osservatorio Geriatrico Regione Campania Group. Diabetes Metab. 1997;23:213- 218.
  31. Greenberg BH, Abraham Wt, Albert NM, et al. Influence of diabetes on characteristics and outcomes in patients hospitalized with heart failure: a report from the Organized Program to Initiate Lifesaving treatment in Hospitalized Patients with Heart Failure (OPtIMIZE-HF). Am Heart J. 2007;154: 277.e1-e8.
  32. Sarma S, Mentz RJ, Kwasny MJ, et al. Association between diabetes mellitus and post-discharge outcomes in patients hospitalized with heart failure: findings from the EVEREST trial. Eur J Heart Fail 2013;15:194–202.
  33. Nieminen MS, Brutsaert D, Dickstein K, et al. EuroHeart Failure Survey II (EHFS II): a survey on hospitalized acute heart failure patients: description of population. Eur Heart J 2006;27:2725–36.
  34. Kapoor JR, Fonarow GC, Zhao X, Kapoor R, Hernandez AF, Heidenreich PA. Diabetes, quality of care, and in-hospital outcomes in patients hospitalized with heart failure. Am Heart J 2011; 162:480–486.e3.
  35. Thomas MC. Anemia in diabetes: marker or mediator of microvascular disease? Nat. Clin. Pract. Nephrol. 2007;3(1):20–30.
  36. Glogner S., Rosengren A., Olsson M., et al. The association between BMI and hospitalization for heart failure in 83,021 persons with Type 2 diabetes: a population-based study from the Swedish National Diabetes Registry. Diabet. Med. 2014;31 (5):586–594.
  37. Anand I, McMurray JJ, Whitmore J, et al. Anemia and its relationship to clinical outcome in heart failure. Circulation. 2004;110(2):149–154.
  38. Glogner S., Rosengren A., Olsson M., et al. The association between BMI and hospitalization for heart failure in 83,021 persons with Type 2 diabetes: a population-based study from the Swedish National Diabetes Registry. Diabet. Med. 2014;31(5):586–594.
  39. Dei Cas et al. Impact of Diabetes on Epidemiology, Treatment, and Outcomes of Patients With Heart Failure. JACC: HEART FAILURE 2015 February; 3(2):136-45.
  40. Boyer JK, Thanigaraj S, Schechtman KB, Pérez JE. Prevalence of ventricular diastolic dysfunction in asymptomatic, normotensive patients with diabetes mellitus. Am J Cardiol. 2004;93:870–875.
  41. Poulsen MK, Henriksen JE, Dahl J, Johansen A, Gerke O, Vach W, et al. Left ventricular diastolic function in Type 2 diabetes mellitus: Prevalence and association with myocardial and vascular disease. Circ Cardiovasc Imaging. 2010;3:24–31.
  42. Jujo K, Minami Y, Haruki S, et al. Persistent high blood urea nitrogen level is associated with increased risk of cardiovascular events in patients with acute heart failure. Esc Heart Failure. 2017;4(4):545-553.
  43. Cowley AW Jr. Role of the renal medulla in volume and arterial pressure regulation. Am J Phys 1997; 273: R1–15.

Corresponding Author

Dr Sumit Sharma

Senior Resident, Department of General Medicine, Mata Gujri Memorial Medical College & LSK Hospital, Purabbali, Dinajpur Road, Kishanganj, Bihar 855108, India

Mobile: 8405009325, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.