Title: Serum C Reactive Protein levels in Stable COPD Patients Attending a Tertiary Care Centre – A Prospective Study
Authors: Dr Sophia Philip, Dr Anitha Thilakan, Dr KGR Mallan, Dr Manjula VD
DOI: https://dx.doi.org/10.18535/jmscr/v6i8.03
Abstract
Chronic Obstructive Pulmonary Disease (COPD) is a major cause of morbidity and mortality throughout the world. C-Reactive protein (CRP) is found in blood plasma, which rises in response to inflammation. A prospective study was conducted in a tertiary care teaching hospital to assess the levels of CRP in stable COPD patients. 100 patients with stable COPD without co-morbidities attending the respiratory OPD were recruited. CRP levels were estimated and patients were followed up for a period of 6 months to check CRP levels serially every 2 months. During exacerbation, CRP was estimated and repeated after 2 weeks of remission, if still positive, again repeated after 2 weeks. Average CRP level was high in a significant number of COPD patients. As the stage of COPD advanced CRP levels were also significantly raised. By applying ANOVA test, average CRP between different stages of COPD was found to be significantly high. Even though current smokers and reformed smokers had high average CRP, statistical significance in mean CRP between them and non smokers were not found. There was a negative correlation between CRP & BMI, but was not statistically significant. There was no significant relationship of CRP with age of the patients. There was negative correlation seen with oxygen saturation, with a significant p value. It was concluded that systemic inflammation is inherent to COPD, independent of smoking status, age & BMI but correlates with disease severity.
Keywords: Stable COPD, CRP, Exacerbation of COPD , systemic Inflammation.
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