Title: Correlation between blood eosinophil count and nasal smear eosinophils with severity of clinical score in allergic rhinitis patients- A cross sectional study
Authors: Dr Jayagar Prabakaran, MBBS, MPH(USA), MS, Dr Elango Dhanapal, DLO, DNB, Prof. Dr Vincent Prasanna, MS, DLO, Dr Sangheetha Jayagar, MBBS
DOI: https://dx.doi.org/10.18535/jmscr/v6i7.187
Abstract
Background: Allergic rhinitis is a common chronic ENT condition which affects the quality of life and causes poor performance in school and at work. Since allergic rhinitis has no single gold standard test, nasal smear eosinophilia and blood absolute eosinophil count could serve as an aid in diagnosis of this chronic disorder.
Objective: To analyze the correlation between blood absolute eosinophil count and nasal smear eosinophilia with clinical score severity in Allergic rhinitis patients.
Material and Methods: Patients aged between 15 and 60 years with a clinical diagnosis of allergic rhinitis were enrolled after obtaining informed written consent. Clinical data recorded and all patients underwent blood investigation for blood absolute eosinophil count and nasal smear for eosinophil count.
Results: The clinical severity had a strong positive correlation with nasal smear eosinophil count (p value 0.001) when compared with that of blood absolute eosinophil count (p value 0.062).
Conclusion: Nasal smear cytology for eosinophils serves as a simple, rapid, semi-invasive investigation for allergic rhinitis diagnosis and can be implemented routinely in regular day to day practice.
Keywords: Allergic rhinitis, Absolute eosinophil count, nasal smear eosinophilia.
References
- Wang DY,Niti M,Smith JD,Yeoh KH,Ng TP.Rhinitis:Do diagnostic criteria affect the prevalence and treatment? Allergy 2002 Feb;57(2):150-4.
- Bachert C. Persistent rhinitis – Allergic or non allergic? Allergy 2004;59:11‑
- Patel AK,Nagpal TP,Comparison of blood absolute eosinophil count and nasal smear eosinophils with symptoms and severity of clinical score in patients with allergic rhinitis.Indian J Allergy Asthma Immunol 2014;28(2):74-76.
- Allergic rhinitis and its impact on asthma-2017 guidelines.J Allergy Clinical Immunol.2017 Oct;140(4):950-958.doi:10.1016/j.jaci.2017.03.050.Epub 2017 Jun 8.
- Comparison of blood eosinophil count and nasal smear eosinophils with symptoms and severity of clinical score in patients of allergic rhinitis.Anand K.Patel, Tapan P.Nagpal.Indian journal of Allergy , Asthma and Immonology. Jul-Dec 2014.Vol 28.Issue 2.
- A Comparative study of nasal smear eosinophils vs absolute eosinophil count in patients with allergic rhinitis. V. Venkates-warlu et al.MRIMS Journal of health sciences,vol 3,issue 1,Jan-June,2015.
- Sanli A, Aydin S, Ates G, Eken M, Celebi O. Comparison of nasal smear eosinophilia with skin prick test positivity in patients with allergic rhinitis. Kulak Burun Bogaz Ihtis Derg 2006;16:60‑
- Chowdary VS, Vinaykumar EC, Rao JJ, Rao R, Rambabu K, Rangamani V. A study of serum IgE and eosinophils in respiratory allergy patients. Indian J Allergy Asthma Immunol 2003;17:21‑
- Jagdeeshwar K, Venumadhav V, Chowdary S, Sudharani V, Kumar V. A study on serum IgE levels, peripheral eosinophils and individual symptoms in patients with non infective rhinitis and asthma and related conditions. Int J Pharm Pharm Sci 2012;4:88‑
- Olusesi AD, Said MA, Amodu EJ. A correlation of symptomatology with nasal smear eosinophilia in non‑infectious chronic rhinitis preliminary report. Niger J Clin Pract 2007;10:238‑
- Chanda R, Kumar A, Aggarwal GS, Kohli GS, Jaswal TS, Gupta KB. Comparative study of nasal smear and biopsy in patients of allergic rhinitis. Indian J Allergy Asthma Immunol 2002;16:27‑31.