Title: Domicilliary use of Oral Mifepristone and Misoprostol in First trimester Medical Abortion

Author: Dr S.V. Nachiketha MD (OBG)

 DOI:  https://dx.doi.org/10.18535/jmscr/v6i2.49

Abstract

Objective: To evaluate medical abortion by Domicilliary administration of mifepristone and Misoprostol by assessing efficacy and women’s acceptability.

Methods: This was a retrospective study of 80 patients done from Jan 2017 to Jan 2018. Women with amenorrhoea of less than or equal to 63 days are advised to self administer 200 mg Mifepristone orally at home on day1. 48 hrs later, oral 800 µg Misoprostol . All women followed up on day 14 of tab. Mifepristone for abortion confirmed by usg.

Results: Efficacy of regimen was 100% in gestational age up to 49 days and 95.45 % in gestational age of 50-63 days. The overall success rate was 97.5%. most of the women were ready to choose same method in future if required.

Conclusion: Medical abortion was simplified by Domicile use of oral mifepristone and Misoprostol as it required less hospital visits and less supervision by trained persons. Acceptability of home self-administration was high. Hence home administration is safe and feasible for introduction into medical abortion services in India.

Keywords: Medical abortion, Mifepristone, Misoprostol.

References

  1. Ngo T D, Park M H, Shakur H, Free C. Comparative effectiveness, safety and acceptability of Medical Abortion at Home and in a Clinic: A Systematic review. Bulletin of the World Health Organization 2011; 89: 360-70
  2. Mundle S, Kalyanwala S, Elul B, Ughade S. Simplifying Medical Abortion: Home Administration of Misoprostol. J Obstet Gynecol India 2008; 58 (5): 410-16.
  3. Chuni N, Chandrashekhar TS. Early pregnancy termination with a simplified Mifepristone: Medical Abortion outpatient regimen. Kathmandu Univ. Med J 2009; 7: 209-12.
  4. Hajri S, Blum J, Gueddana N, Saadi H, Maazoun L, Che’lli H, et al. Expanding medical abortion in Tunisia: Women’s experiences from a multisite expansion study. Contraception 2004; 70: 487-91
  5. Raghavan S, Comendant R, Digol I, Ungureanu S, Dondiuc I, Turcanu S, Winikoff B. Two pill regimens of Misoprostol after Mifepristone medical abortion through 63 days gestational age: Randomized control trial of sublingual and oral Misoprostol. Contraception 2009; 79: 513- 9.
  6. Hamoda H, Ashok P W, Flett GM, Templeton A. Home self administration of Misoprostol for Medical Abortion up to 56 days Gestation. J Fam Plann Reprod Health care 2005; 31: 189-92
  7. Bracken H, Family Planning Association of India/ Gynuity Health Project Research Group for Simplifying Medical Abortion in India. Home administration of Misopr-ostol for early Medical abortion in India. Int J of Gynecol Obstet; 2010; 108:228-32.
  8. Guengant J P, Bangou J, Elul B, Ellertson C. Mefipristone-Misoprostol medical abortion: Home administration of Misoprostol in Guadeloupe. Contraception 1999; 60:167-72.

Corresponding Author

Dr S.V. Nachiketha MD (OBG)

Associate Prof, OBG, KIMS Hubballi

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