Title: Preoperative Skin Preparation with Chlorhexidine Alcohol and Povidone Iodine: A Comparative Study

Authors: Ragesh Kalikkottu Valappil, Perumbrayoor Thacharampurathu Sajesh, Sheena Krishnan

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i12.129

Abstract

Background: Surgical Site Infections are the third most commonly reported nosocomial infections all over the world1. Patient's skin is a major source of pathogens that cause Surgical Site Infection. Povidone-Iodine (5%) is being used for preoperative skin preparation in surgeries since 1955 and is preferred universally. But it fails to control surgical site infection which is a major post operative complication.. Chlorhexidine alcohol has been widely used as an oral antiseptic solution and its efficacy has been recently made it as an antiseptic and disinfectant2. This study compares the efficacy of Chlorhexidine-Gluconate (2.5%v/v) & Isopropyl Alcohol (63%) to Povidone-Iodine (5%) in preventing surgical site infections in elective midline laparotomy surgeries.

Aim of Study: To compare the efficacy of chlorhexidine alcohol versus povidone iodine for pre-operative skin preparation in preventing surgical site infection in elective midline laparotomies.

Materials and Methods: A total of 200 patients were taken for this study.  100 patients underwent draping with chlorhexidine alcohol (Group A) who were compared with 100 patients who underwent draping with povidone iodine (Group B). Variables used in this study are wound infection and ASEPSIS score.

Results: In the povidone-iodine group 14 (14%) patients had wound infection and in the chlorhexidine alcohol group 10(10%) patients had wound infection. Even though SSI is lower in chlorhexidine group, the difference was not statistically significant (p value 0.384).

Conclusion: There is no significant difference between chlorhexidine alcohol and povidone iodine in preventing surgical site infection in elective midline laparotomy surgeries.

Keywords: Chlorhexidine Alcohol, Povidone Iodine, ASEPSIS score.

References

  1. Patel NP. Antimicrobial Agents for Surgical Infections. Surg Clin of North Am April2009;89:365-90.
  2. Brunicardi CF. Surgical Infections. Schwartz's Principles of Surgery, McGraw Hill Company, 9thInternational edition, 2010p.132-88.
  3. Noorani A, Rabey N, Walsh SR, Davies RJ. Systematic review and meta-analysis of preoperative antisepsis with chlorhexidine alcohol versus povidone–iodine in clean-contaminated surgery. Br J Surg.2010; 97(11):1614–162.
  4. Dumville JC, McFarlane E, Edwards P, Lipp A, Holmes .A Preoperative skin antiseptics for preventing surgical wound infections after clean surgery. Cochrane Database Syst Rev2013, Issue 3. Art. No.: CD003949
  5. Patil RA,Gaikwad VV,Kulkarni RM. A Comparative Study Of chlorhexidine alcohol Versus Povidone-Iodine For Surgical Site Antisepsis In Clean & Clean Contaminated Cases. Journal of Medical Thesis 2013 July -Sep; 1(1):33-34
  6. Darouiche RO, Wall MJ Jr, Itani KM, Otterson MF, Webb AL, Carrick MM, et al. chlorhexidine alcohol versus Povidone-Iodine for Surgical-Site Antisepsis N Engl J Med. 2010 Jan 7; 362(1):18-26
  7. 7Shooter RA, Taylor GW, Ellis G, et al. Postoperative wound infection. Surgery Infect Dis ObstetGynecol1956;103(3):257-262.
  8. Horan TC, Gaynes RP, Martone WJ. CDC definitions of nosocomial surgical site infections, 1992: a modification of CDC definitions of surgical wound infections. Infect Control Hospepidemiol 1992;13 (10):606-608.
  9. Langgartner J, Linde HJ, Lehn N, et al. Combined skin disinfection with chlorhexidine alcohol/propanol and aqueous povidone-iodine reduces bacterial colonization of central venous catheters. Intensive Care Med 2004;30(6):1081-1088.
  10. Hemani ML, Lepor H. Skin preparation for the prevention of surgical site infection: which agent is best? Rev Urol 2009;11(4):190–5.
  11. Darouiche RO, Wall MJ Jr, Itani KM, Otterson MF, Webb AL, Carrick MM, et al. Chlorhexidine alcohol-alcohol versus povidone-iodine for surgical-site antisepsis. N Engl J Med 2010;362(1):18–26.
  12. Plowman R, Graves N, Griffin MA, et al. The rate and cost of hospital-acquired infections occurring in patients admitted to selected specialties of a district general hospital in England and the national burden imposed. J Hosp Infect 2001;47:198–209.
  13. Culligan PJ, Kubik K, Murphy M, et al. A randomized trial that compared povidone iodine and chlorhexidine as antiseptics for vaginal hysterectomy. Am J ObstetGynecol 2012;192(2):422-425.
  14. Danasekaran G, Rasu S, Palani M. A study of comparative evaluation of preoperative skin preparation with chlorhexidine-alcohol versus povidone-iodine in prevention of surgical site infections. Journal of Evidence based Medicine and Health Care 2017; 4 (4): 2453-2460.
  15. Lynch W, Davey PG, Malek M, et al. Cost-effectiveness analysis of the use of chlorhexidine alcohol detergent in preoperative whole-body disinfection in wound infection prophylaxis. J Hosp Infect1992;21:179–91.
  16. Webster J. Preoperative bathing or showering with skin antiseptics to prevent surgical site infection. Cochrane Database of Syst Rev2007;(2):CD004985.

Corresponding Author

Sheena Krishnan

Department of Microbiology,

Government Medical College, Kozhikode, Kerala, India

Mobile Number: +919847193171, Email: This email address is being protected from spambots. You need JavaScript enabled to view it.