Title: Comparison of Ulcer Healing Property of Lansoprazole and Rabeprazole in Albino Rats
Authors: Dr Syed Md. Javed, Dr Md. Ishtiaque Ahmad
DOI: https://dx.doi.org/10.18535/jmscr/v5i6.225
Abstract
Proton pump inhibitors (PPIs) are a group of drugs whose main action is a pronounced and long-lasting reduction of gastric acid production. Medically used proton pump inhibitors are Omeprazole, Lansoprazole, Dexlansoprazole, Esomeprazole, Pantoprazole, and Rabeprazole Hence this study is planned with the aim to compare outcome of lansoprazole & rabeprozole for gastric ulcer healing in albino rats.
Total 15 albino rates were used in the study and divided in 3 groups of 5 each. The control study group and drug administered group were divided for the comparison. Aspirin was administered 200mg/kg of body weight for generation of gastric ulcers. Lansoprazole was administered 30 mg/kg of body weight and Rabeprazole was administered 20 mg/kg of body weight.
In the control group of rats the average weight of the albino rats was observed as 230 to 240 gm. In this study group ulcers percentage is 100% with the Ulcer Index as 6.2 – 6.5. In the Lansoprazole drug induced study group the weight was 245 to 256 gms. The ulcer percentage was recorded as 67% with the ulcer index in the range of 3.2 to 3.4. In the Rabeprazole drug induced patients the ulcer percentage was observed as 35% with the reduced ulcer index to 1.1-1.4 compared to previous study group rats.
Hence form the present study it can be concluded that the Rabeprazole is more effective to control the peptic ulcer than the Lansoprazole in albino rats. This study further needs to be elaborated in patients with peptic ulcer to know the actual effect and onset of action.
Keywords: Lansoprazole, rabeprozole, peptic ulcer, healing capcity, albino rats, etc.
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