Title: Low Dose Computed Tomography (LDCT) Versus Chest X-ray in Chronic Smokers- Can LDCT be Used as a Motivation to Quit Smoking?

Authors: Dr Tosha Jatin Desai, Dr Ekta Vinubhai Vadher, Dr Nandini Umesh Bahri

 DOI:  https://dx.doi.org/10.18535/jmscr/v5i6.60

Abstract

Background- Smoking is one of the biggest health threats to mankind. Early diagnosis of pulmonary changes induced by smoking can help in timely intervention and prediction of course of smoking-induced diseases.

Aim-The aim of this study was to determine the relative prevalence of various common radiological findings associated with smoking and compare their detection on digital chest X-ray and Low Dose Computed Tomography (LDCT)

Materials and Methods-Chest X-ray PA view and LDCT scan of 50 chronic symptomatic/asymptomatic male smokers were analysed over a period of 1 year from February 2016 to February 2017.

Summary- Chest X-ray was less sensitive in detecting early emphysematous changes, small pulmonary nodules and minimal fibro-bronchieactatic changes. In our study, spectrum of respiratory findings in smokers on LDCT included bronchial thickening (68%) emphysema (66%), interstitial thickening (61%), pulmonary micro- and macro- nodules, air space opacification, bronchieactasis, mediastinal lymphadenopathy and ground-glass opacities. The sensitivity of LDCT in diagnosing malignant lesions was 88.4% and speceficity was 82.5%. The sensitivity of Chest Xray in diagnosing malignant lesions was 50% and specificity was 87.5%.

Conclusion- LDCT diagnoses malignant lesions much earlier and provides a better graphical picture of the pathology under study to young and middle aged smokers willing to quit smoking. Since the baseline risk of lung cancer development is small and the dose exposure in a single LDCT scan is well below the annual adult radiation dose limit, the risk-benift ratio is very favourable.

Keywords-smoking, smoking-induced diseases, Chest X-ray, LDCT, risk-benifit ratio.

References

1.    1.      World Health Organisation. Tobacco [Inte-rnet]. Geneva: World Health Organisation; 2017 May [cited 2017 June 1]. Available from:

2.      http://www.who.int/mediacentre/factsheets/fs339/en/

3.      Galvin JR, Franks TJ. Smoking-related lung disease. Journal of thoracic imaging. 2009 Nov 1;24 (4):274-84.

4.      Mayo clinic.Chest X-rays.[Internet]2014 May [cited 2017 June 1]. Available from:

5.      http://www.mayoclinic.org/tests-procedures/chest-x-rays/basics/definition/prc-20013074

6.      Cardinale L, Volpicelli G, Lamorte A, Martino J, Veltri A. Revisiting signs, strengths and weaknesses of Standard Chest Radiography in patients of Acute Dyspnea in the Emergency Department. Journal of thoracic disease. 2012 Aug;4 (4):398.

7.      National Lung Screening Trial Research Team. The national lung screening trial: overview and study design. Radiology. 2011.

8.      Sharma D, Newman TG, Aronow WS. Lung cancer screening: history, current perspectives, and future directions. Archives of medical science: AMS. 2015 Oct 12;11(5):1033.

9.      Gorycki1ABCDEF T, Lasek1BD I, Kamiński2CD K, Studniarek1DE M. Evaluation of radiation doses delivered in different chest CT protocols.

10.  Kauczor HU, Bonomo L, Gaga M, Nackaerts K, Peled N, Prokop M, Remy-Jardin M, von Stackelberg O, Sculier JP, European Society of Radiology (ESR. ESR/ERS white paper on lung cancer screening. European radiology. 2015 Sep 1;25 (9):2519-31.

11.  Kirchner J, Goltz JP, Lorenz F, Obermann A, Kirchner EM, Kickuth R. The “dirty chest”—correlations between chest radiography, multislice CT and tobacco burden. The British journal of radiology. 2014 Feb 13.

12.  Blanchon T, Bréchot JM, Grenier PA, Ferretti GR, Lemarié E, Milleron B, Chagué D, Laurent F, Martinet Y, Beigelman-Aubry C, Blanchon F. Baseline results of the Depiscan study: a French randomized pilot trial of lung cancer screening comparing low dose CT scan (LDCT) and chest X-ray (CXR). Lung Cancer. 2007 Oct 31;58(1):50-8.

13.  Villanti AC, Jiang Y, Abrams DB, Pyenson BS. A cost-utility analysis of lung cancer screening and the additional benefits of incorporating smoking cessation intervene-tions. PloS one. 2013 Aug 7;8(8):e71379.

Corresponding Author

Dr Tosha Jatin Desai

Kanti’, 102/C Mahavir C society, Near Shivam Paan Center,

Jamnagar, Gujarat, India